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Multiple studies showed the numerous advantages of implementing programmed epidural bolus (PIEB) technique, where a fixed volume of local anesthetic is automatically administrated at a set time interval compared to the continuous epidural infusion technique (CEI). The advantages were improved maternal satisfaction, decreased local anesthetic consumption, and decreased second stage of labor.The theory behind PIEB is that to attain a more uniform spread of local anesthetic in the epidural space a higher volume of injectate and a higher pressure is needed.Different approaches using different timings and volumes for PIEB have been proposed to achieve the optimal regimen. Many studies showed evidence that 10 mL boluses of bupivacaine 0.0625% with fentanyl 2 μg/mL delivered every 40 min, named effective programed intermittent epidural bolus interval 90 (EI90), produced effective analgesia without breakthrough pain in 90% of nulliparous women during the first stage of labor.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nulliparous | Active Comparator | Patients of ASA physical status 2-3 with a singleton pregnancy; gestational age > 37 weeks; regular uterine contractions occurring at least every 5 min; cervical dilation 2-5 cm; and pain > 5 |
|
| Multiparous | Active Comparator | Patients of ASA physical status 2-3 with a singleton pregnancy; gestational age > 37 weeks; regular uterine contractions occurring at least every 5 min; cervical dilation 2-5 cm; and pain > 5 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| programed intermittent epidural bolus interval 90 (EI90) | Device | programed intermittent epidural bolus interval 90 (EI90) of 10 ml, 0.0625% bupivacaine plus 2 μg/mL fentanyl |
|
| Measure | Description | Time Frame |
|---|---|---|
| adequate labour analgesia | Time of first call for bolus dose of epidural After loading dose | six hours |
| Measure | Description | Time Frame |
|---|---|---|
| Upper sensory block | Secsensory block level to ice | 24hours |
| Visual Analogue Scale to pain | As zero is no pain and 10 is the maximum pain that can be felt |
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Inclusion Criteria:
Exclusion Criteria:
Nulliparous and multiparous women
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Medicine Menoufia University | Cairo | Governorate | 32511 | Egypt | ||
| Rabab Habeeb |
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| ID | Term |
|---|---|
| D048949 | Labor Pain |
| ID | Term |
|---|---|
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| 24 hours |
| Motor block | Motor block measured by bromage scale | 24 hours |
| Total anaesthetic volume | Total volume of local anesthetic used | 24 hours |
| Side effects | Presence of side effects as neusea, vomiting,peruritis | 24 hours |
| Cairo |
| Governorate |
| 32817 |
| Egypt |