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Recent studies showed that the value of c100A12 increased in children with Kawasaki disease, and decreased rapidly after treatment with gamma globulin. In kawasaki disease with coronary artery dilatation, S100A12 levels are elevated in the acute phase of Kawasaki disease and continue for some time in the convalescence phase before gradually decreasing. However, the number of patients included in previous studies was small and the follow-up time was short. In this study, 100 children with Kawasaki disease who were admitted to Wuhan Children's Hospital, Jingzhou First People's Hospital and Renhe Hospital affiliated to China Three Gorges University from December 2021 to December 2023 were selected as the research objects, and 100 children with healthy physical examination were selected as the control group during the same period. To investigate whether S100A12 increased significantly in the acute phase of Kawasaki disease compared with a healthy control group. To study whether S100A12 value increased rather than decreased in kawasaki disease that did not respond to gamma globulin treatment after gamma globulin treatment. At the same time, to study whether the increase of S100A12 in kawasaki disease convalescence indicates coronary aneurysm.
S100A12 was determined using the ELISA kit and according to the instructions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Kawasaki disease | All children with Kawasaki disease met the diagnostic criteria for Kawasaki disease revised by the American Heart Association in 2017. |
| |
| Healthy controls | Healthy control group were healthy children who underwent outpatient physical examination. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| S100A12 | Diagnostic Test | The early dynamic detection of S100A12 was used to determine whether it was an auxiliary diagnostic index for Kawasaki disease |
|
| Measure | Description | Time Frame |
|---|---|---|
| S100A12 | S100A12 was increased in children with Kawasaki disease and decreased after gamma globulin treatment | From date of randomization until the date of first documented progression, whichever came first, assessed up to 18 months |
| Measure | Description | Time Frame |
|---|---|---|
| CRP | Measure the CRP value | From date of randomization until the date of first documented progression, whichever came first, assessed up to 18 months |
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Inclusion Criteria:
â–ªDiagnostic criteria of Kawasaki disease revised by the American Heart Association in 2017
Exclusion Criteria:
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The case group consisted of 50 hospitalized children with Kawasaki disease. The healthy control group consisted of 50 healthy children.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yan Pan, Dr. | Contact | 08618163139706 | woshipanyan@126.com | |
| Qihong Fan, Dr. | Contact | 08618972161050 | jzfqh163@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Qihong Fan, Dr. | Yangtze University | Principal Investigator |
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