The Effect of Remifentanil on ED95 of Remimazolam for Loss of Consciousness in Adult Patients

The Effect of Remifentanil on ED95 of Remimazolam for Loss of Consciousness in Adult Patients

This study prospectively uses the biased coin technique to investigate the effect of concomitant administration of remifentanil on the 95% effective dose of intravenous remimazolam (Effective dose 95 [ED95]) required for loss of consciousness during anesthesia induction. .

Inclusion Criteria:

• The adult patients who are scheduled to surgery under general anesthesia

Exclusion Criteria:

• Severe obesity (BMI > 30 kg/m2)
• Allergy to remimazolam or remifentanil
• Under conditions which make it difficult to respond to the investigator's verbal commends like hearing impairment, etc.
• Patients with general conditions are more than ASA class III
• Patients with brain disease (dementia, cerebral infarction, etc.)