The purpose of this study is to find out if it is practical to provide 2 interventions, VMB exercise classes and EUC (pre-recorded self-care videos), during the perioperative period (before and after surgery) to improve health-related outcomes and quality of life for people undergoing a pancreatectomy.

Inclusion Criteria:

• Age ≥ 18 years or older
• Any pancreas disease (benign, pre-malignant, or malignant) and will be undergoing pancreatectomy
• Has at least one week to participate in the study prior to the anticipated surgery date
• Eastern Cooperative Oncology Group (ECOG) Performance status 0 or 1
• English-speaking only

Exclusion Criteria:

• Unable to give informed consent due to cognitive impairment or impaired decisionmaking capacity
• Cognitive impairment precluding response to study assessments
• Received neoadjuvant or any chemoradiation in the past 60 days
• Unwilling to accept random assignment
• Unwilling to commit to the 12-week study time period
• Unlikely to be compliant because of social factors that prevent patients from attending classes or doing home practice (e.g., unreliable internet, no access to a computer)

Memorial Sloan Kettering Cancer Center supports the international committee of medical journal editors (ICMJE) and the ethical obligation of responsible sharing of data from clinical trials. The protocol summary, a statistical summary, and informed consent form will be made available on clinicaltrials.gov when required as a condition of Federal awards, other agreements supporting the research and/or as otherwise required. Requests for deidentified individual participant data can be made beginning 12 months after publication and for up to 36 months post publication. Deidentified individual participant data reported in the manuscript will be shared under the terms of a Data Use Agreement and may only be used for approved proposals. Requests may be made to: crdatashare@mskcc.org.