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| Name | Class |
|---|---|
| Prof. Pietro Giorgio Calò | UNKNOWN |
| Dott. Gian Luigi Canu | UNKNOWN |
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Indeterminate thyroid nodules have a mild risk of malignancy (15-30%). The aim of our study is to individuate new biomarkers of thyroid carcinoma through multiomic analyses of blood samples and of specimen samples of patients with indeterminate thyroid nodules.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Thyroid carcinoma | Patients with indeterminate thyroid nodule and pathological diagnosis of thyroid carcinoma |
| |
| Follicular adenoma | Patients with indeterminate thyroid nodule and pathological diagnosis of follicular adenoma |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Multiomic analyses of blood and surgical specimens | Diagnostic Test | The following items will be evaluated:
|
| Measure | Description | Time Frame |
|---|---|---|
| Identification of biomarkers of thyroid carcinoma | Identification of alterations in cfDNA length and integrity, presence of SNPs in cfDNA, alterations of serum proteome predictive of thyroid carcinoma | 50 months |
| Measure | Description | Time Frame |
|---|---|---|
| Elaboration of diagnostic algorithm | Elanoration of diagnostic algorithm predictive of thyroid carcinoma through integration of clinical, ultrasonographic and multiomic variables able to predict che condition of thyroid cancer in patients with indeterminate thryoid nodules | 60 months |
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Inclusion Criteria:
Exclusion Criteria:
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We plan to include in our study patients with indeterminate thyroid nodules (Class III and Class IV according to Bethesda classification) who have a mild risk of thyroid cancer (15-30%)
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AOU Cagliari | Cagliari | CA | 09100 | Italy |
Individual participant data will be available under reasonable request
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|
| ID | Term |
|---|---|
| D016606 | Thyroid Nodule |
| D013964 | Thyroid Neoplasms |
| ID | Term |
|---|---|
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D006258 | Head and Neck Neoplasms |
| D004700 | Endocrine System Diseases |
| D013959 | Thyroid Diseases |
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