The Influence of Daily Honey Consumption on IR in Obese Women With IR

The Influence of Daily Honey Consumption on Insulin Resistance in Obese Women With Insulin Resistance

The main objective of the study is to evaluate the effects of daily honey consumption on insulin resistance as a preventive measure against diabetes. in women with insulin resistance.

The prevalence rates of insulin resistance (IR) and its health consequences are increasing worldwide. The reputation of honey as a healthy alternative for sugar is largely accepted. Honey contains several bioactive constituents; however, its effect on IR measures and glycemic control is yet to be assessed. We aim to evaluate the effect of daily consumption of honey on IR and inflammatory status measures in obese women with insulin resistance in a free-living controlled intervention study. Sixty obese adult females with insulin resistance will be recruited from the community of the University of Jordan and from patients at the Endocrine unit at the University of Jordan Hospital. Participants will be randomly assigned into one of two treatment groups, honey group or jell-O group. Participants will consume a daily dose of 0.5 mg per kg of body weight of the prescribed treatment for 6 months. The effects of daily consumption of honey on IR, serum concentration of several inflammatory biomarkers, and body fatness will be evaluated. The results of this study would reveal the antidiabetic effect of the bioactive compounds in honey in insulin-resistant obese women.

Inclusion Criteria:

• Female
• 19-45 years
• Obese (BMI >= 30 kg/m^2)
• Premenopausal

Exclusion Criteria:

• Individual who use any drug or supplements known to affect lipid, glucose for at least the last three months.
• Individual who previous insulin treatment
• Smokers
• Individual who have diabetes, kidney, liver, or hormonal diseases
• Individual who have significant weight changes > 5% during the past 6 months
• Women who are postmenopausal