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This study will investigate the effect of caffeine and time of day on brain excitability using excitatory brain stimulation. The investigators will recruit a healthy participant and conduct a concurrent iTBS/fNIRS protocol for 20 consecutive sessions over four weeks with or without caffeine consumption before the stimulation. Moreover, the experiment will be conducted at different times of the day (morning or afternoon)
One healthy participant will be recruited for this study. The participants will be subjected to concurrent TBS/fNIRS, to which the iTBS will be applied on the left DLPFC and the NIRS will measure the prefrontal hemodynamic response simultaneously.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cortical hemodynamic variability of four weeks iTBS | Experimental | One healthy participant will be included in this study, which lasts for 4 weeks, 5 visits per week, involving 20 visits in total. The participant will receive the following instructions the night before: to take 200 mg of caffeine one hour before the visit (no other caffeine intake since the wake-up) or avoid caffeine intake at all before the visit; to attend the visit in the morning or afternoon. These assignments will be randomized in a counterbalanced manner. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| caffeine | Other | The investigators will ask participant to only intake 200 mg of caffeine one hour before the experiment (no other caffeine intake since the wake-up) or avoid caffeine intake at all before the experiment |
| Measure | Description | Time Frame |
|---|---|---|
| Oxygenated hemoglobin (HbO) change compared to baseline | iTBS-induced HbO change in the DLPFC before, during and after stimulation | During and post TBS-fNIRS measurement, up to 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Deoxygenated hemoglobin (HbR) change compared to baseline | iTBS-induced HbO change in the DLPFC before, during and after stimulation | During and post TBS-fNIRS measurement, up to 1 month |
| Oxygen saturation change compared to baseline |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Georg S Kranz, PhD | The Hong Kong Polytechnic University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Hong Kong Polytechnic University | Hong Kong | Hong Kong |
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| ID | Term |
|---|---|
| D002110 | Caffeine |
| ID | Term |
|---|---|
| D014970 | Xanthines |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D011688 | Purinones |
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One healthy participant will undergo four weeks of concurrent TBS/fNIRS to investigate the cortical hemodynamic variability
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| Experimental time | Other | The investigators will ask participant to attend the experiment in the morning or afternoon |
|
iTBS-induced HbO change in the DLPFC before, during and after stimulation
| During and post TBS-fNIRS measurement, up to 1 month |
| D011687 |
| Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |