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| Name | Class |
|---|---|
| Xian Daxing Hospital | UNKNOWN |
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This study is aimed to investigate the post-stroke motor recovery of patients with ischemic stroke based on their neural features extracted from EEG-fMRI data.
A group of patients with ischemic stroke and age/gender matched healthy controls would be enrolled in this study. Their features of neural activities based on EEG-fMRI fusion scan would be extracted to investigate the mechanisms of motor recovery after stroke. Particularly, the correlations of their features of neural networks or local activities to their motor function (defined as their Fugl-Meyer scores) at enrollment and their recovery time courses consisted of Fugl-Meyer scores in follow-up time points. Data of T1 structural, DSI fiber image and pure EEG (without MRI) would also be collected along with EEG-fMRI fusion data.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High Recovery | Effective recovery rate defined as difference between Fugl-meyer scores in the 6 weeks after stroke onset (eF) and in the enrollment (sF) normalized by (total score-sf) would be used to indicate the recovery Level of a patients, i.e., (eF-sF)/ (total score-sf). A previously reported recovery rate, i.e., proportional recovery((eF-sF)/(total score-sf)=0.7) was chosen as a standard of a high recovery. Patients with effective recovery rate higher than 0.7 at the T1 time point (6 weeks after stroke onset) would be assigned to group with high recovery rate |
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| Low Recovery | The Low Recovery group indicates that patients with effective recovery rate lower than 0.7 |
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| Healthy Control | Age/sex matched healthy subjects enrolled to compare with group of patients. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MRI recording | Diagnostic Test | MRI imaging was performed using a 3 Tesla Siemens Prisma system with a 64-channel head/neck coil (Siemens Medical Systems, Erlangen, Germany). The MRI protocols included as follows: (i) Magnetization-Prepared 2 Rapid Acquisition Gradient Echoes: TR/TE/ TI1/TI2 = 5000/2.98/700/2500 ms, voxel size = 1.0 × 1.0 × 1.0 mm3, FOV = 256 × 240 × 176 mm3; (ii)Gradient-echo EPI: TR 720 ms, TE 33.1 ms, flip angle 52 deg, FOV 208x180 mm, Matrix 104x90, Slice thickness 2.0 mm; 72 slices; 2.0 mm isotropic voxels, Multiband factor 8, Echo spacing 0.58 ms, BW 2290 Hz/Px; (iii) DSI : TR/TE = 3300/73 ms, FOV = 220 × 220 × 60 mm3, voxel size = 2 × 2 × 2 mm3, 128 diffusion direction, b-max = 3000 sec/mm2, AT = 7:22 min); (iv) T2-weighted fluid-attenuated inversion recovery: TR/TE = 9000/84 ms, FOV = 270 × 320 × 22 mm2, voxel size = 0.72 × 0.72 × 6.6 mm3. |
| Measure | Description | Time Frame |
|---|---|---|
| Fugl-Meyer scores (T0) | a scale widely used to evaluate one's motor impairment | 7-14 days since stroke |
| Fugl-Meyer scores (T1) | a scale widely used to evaluate one's motor impairment | 6 weeks since stroke |
| Fugl-Meyer scores (T2) | a scale widely used to evaluate one's motor impairment | 12 weeks since stroke |
| Fugl-Meyer scores (T3) | a scale widely used to evaluate one's motor impairment | 72 weeks since stroke |
| Measure | Description | Time Frame |
|---|---|---|
| Neuroimage features based on EEG-fMRI (T0) | Neuroimage features extracted from EEG-fMRI data | 7-14 days since stroke |
| Neuroimage features based on EEG-fMRI (T1) | Neuroimage features extracted from EEG-fMRI data |
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Inclusion Criteria:
Exclusion Criteria:
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AA population with motor impairment induced by first-ever stroke in a specific duration (7-14 days after stroke attack, i.e., early subacute stage) would be enrolled to investigate the mechanisms of post-stroke recovery of motor function.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xi'an Daxing Hospital | Xi’an | Shanxi | 710016 | China |
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| ID | Term |
|---|---|
| D009443 | Neuritis |
| D000083242 | Ischemic Stroke |
| ID | Term |
|---|---|
| D010523 | Peripheral Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
| D009422 | Nervous System Diseases |
| D020521 | Stroke |
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| EEG recording | Diagnostic Test | EEG was performed using a BrainAmp MR 32 amplifier (BrainProducts GmbH, München, Germany). The EEG protocols included as follows: (i) EEG-fMRI fusion: Sampling rate: 5000 Hz, low cut off-high cut off: DC-1000Hz;(2) EEG-fMRI fusion: Sampling rate: 1000 Hz, low cut off-high cut off: DC-1000Hz. In (i) an ECG channel would be used to collect artifact of pulse and not used in (ii). |
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| 6 weeks since stroke |
| Neuroimage features based on EEG-fMRI (T2) | Neuroimage features extracted from EEG-fMRI data | 12 weeks since stroke |
| Neuroimage features based on EEG-fMRI (T3) | Neuroimage features extracted from EEG-fMRI data | 72 weeks since stroke |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |