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| Name | Class |
|---|---|
| Region Stockholm | OTHER_GOV |
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The present pilot study will investigate the prevalence of CMD in an unselected cohort of patients with the working diagnosis MINOCA and to study if the diagnostic yield can be improved by adding adenosine to the CMR investigation. Patient will be their own controls.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with MINOCA undergoing CMR | Other | Patients will be their own controls |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cardiac magnetic resonance imaging to study coronary microvascular dysfunction | Diagnostic Test | Myocardial perfusion mapping will be investigated after administration of adenosine |
| Measure | Description | Time Frame |
|---|---|---|
| Diagnostic yield | To increase the diagnostic yield of CMR imaging in MINOCA as a working diagnosis | Through investigation completion, usually 2 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of CMD in MINOCA | To determine the proportion of patients with the working diagnosis of MINOCA who have CMD. | Through investigation completion, usually 2 hours |
| Prevalence of CMD in different final MINOCA diagnoses |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Per Tornvall, MD | Contact | +468616100 | per.tornvall@ki.se | |
| Peder Sörensson, MD | Contact | +46812370000 | perder.sorensson@regionstockholm.se |
| Name | Affiliation | Role |
|---|---|---|
| Per Tornvall, MD | Karolinska InstÃtutet | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Per Tornvall | Recruiting | Stockholm | 11551 | Sweden |
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| ID | Term |
|---|---|
| D000088442 | MINOCA |
| ID | Term |
|---|---|
| D009203 | Myocardial Infarction |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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Patients will be their own controls
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The investigators who will perform the evaluation of the CMR investigations will be blinded to all clinical data.
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To study the proportions of CMD in patients with a CMR imaging diagnosis of myocardial infarction, Takotsubo, respectively myocarditis and compare them with the results from a healthy control group
| Through investigation completion, usually 2 hours |
| Angina pectoris | To investigate the occurrence of angina pectoris before inclusion and after 3 months and relate it to CMD | 3 Months |
| D014652 |
| Vascular Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |