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This study will examine the effect of TMS on people with stroke and aphasia as well as healthy individuals.
To examine the brain's structure and specific language function and interactive relationships, investigators will implement repetitive or rapid TMS protocols in an active (or sham)-controlled, within-subject, randomized studies. Aims will evaluate the effects of short-term changes on each of the semantic or phonological language process of interest in isolation and changes in the interaction between language sub-processes and their interaction with other cognitive domains that directly or indirectly affect language functions. The brain targets for TMS application will be informed by existing evidence on (correlational but not causal) associations between language regions and specific language processes from numerous prior neuroimaging (e.g., functional magnetic resonance imaging or fMRI) and neuropsychological studies. Healthy individuals and/or stroke survivors with aphasia will be recruited to address these aims.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active TMS | Experimental | Deymed DuoMag XT-100 rTMS system (DM-XT100) connected to a 70-mm figure-of-eight coil with built-in cooling fans (also known as an air-cooled coil) will be used for delivering active repetitive or rapid TMS to the target site. |
|
| Control TMS | Active Comparator | Deymed DuoMag XT-100 rTMS system (DM-XT100) connected to a 70-mm figure-of-eight coil with built-in cooling fans will be used for delivering active repetitive or rapid TMS to the control site. |
|
| Sham TMS | Sham Comparator | Deymed DuoMag XT-100 rTMS system (DM-XT100) connected to a 70-mm figure-of-eight coil with built-in cooling fans will be used for delivering sham repetitive or rapid TMS to the control or target site. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial Magnetic Stimulation | Device | Deymed DuoMag XT-100 rTMS |
|
| Measure | Description | Time Frame |
|---|---|---|
| Reaction time on language task performance | Improvement on language task performance as measured by decrease in reaction time. | Language tasks administered immediately before and/or after TMS administration (same day). |
| Accuracy on language task performance | Improvement on language task performance as measured by increase in accuracy. | Language tasks administered immediately before and/or after TMS administration (same day). |
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Inclusion Criteria:
Exclusion Criteria:
Severe cognitive, auditory or visual impairments that would preclude cognitive and language testing
Non-decisional per decisionality questionnaire or other clinical assessment
Presence of major untreated or unstable psychiatric disease (e.g. schizophrenia, bipolar disease)
A chronic medical condition that is not treated or is unstable
Presence of
Pregnancy
History of skull fractures, or skin diseases
History of ongoing or unmanaged seizures or a family history of epilepsy
Presence of factors that potentially decrease seizure thresholds
On pro-convulsant medications
Untreated Sleep deprivation or insomnia
Ongoing alcoholism or illegal drug abuse (e.g., cocaine or MDMA users)
History of dyslexia or other developmental learning disabilities
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sidney Schoenrock | Contact | 414-955-7579 | sschoenrock@mcw.edu |
| Name | Affiliation | Role |
|---|---|---|
| Priyanka Shah-Basak, PhD | Medical College of Wisconsin | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical College of Wisconsin | Recruiting | Milwaukee | Wisconsin | 53226 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 9153480 | Background | Chen R, Classen J, Gerloff C, Celnik P, Wassermann EM, Hallett M, Cohen LG. Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation. Neurology. 1997 May;48(5):1398-403. doi: 10.1212/wnl.48.5.1398. | |
| 17138570 | Background | Devlin JT, Watkins KE. Stimulating language: insights from TMS. Brain. 2007 Mar;130(Pt 3):610-22. doi: 10.1093/brain/awl331. Epub 2006 Nov 29. |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| D001037 | Aphasia |
| D007802 | Language |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
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Multiple studies will be conducted in parallel. But within a study, the interventional assignment will be set to cross-over with 3-4 arms.
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The participant and outcomes assessor will both be blinded to intervention modalities.
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| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D013064 | Speech Disorders |
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003142 | Communication |
| D001519 | Behavior |