Cologne Placenta Cohort (CPC)

Study to Investigate Signaling Pathways in Placentas of Overweight or Obese Patients and Patients With Gestational Diabetes Mellitus

Aim of the study was to determine if signaling pathways in placentas of mothers affected by overweight/obesity or by gestational diabetes are altered compared to placentas of a control group (normal weight, no gestational diabetes). Moreover, maternal blood and umbilical cord blood were analysed.

Inclusion Criteria:

• singleton pregnancy
• BMI before pregnancy >= 18
• with & without gestational diabetes
• c-section at gestational week 35+0 until 41+6

Exclusion Criteria:

• multiple pregnancy
• maternal serious internal disease
• infections before pregnancy (e.g. HIV, hepatitis B)
• pregnancy-associates diseases (e.g. gestoses, androgen insensitivity syndrome)