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Aim of the study was to determine if signaling pathways in placentas of mothers affected by overweight/obesity or by gestational diabetes are altered compared to placentas of a control group (normal weight, no gestational diabetes). Moreover, maternal blood and umbilical cord blood were analysed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| normal weight without gestational diabetes | BMI < 25; normal glucose tolerance |
| |
| normal weight with gestational diabetes | BMI < 25; impaired oral glucose tolerance |
| |
| overweight without gestational diabetes | BMI 25 - 29.9; normal glucose tolerance |
| |
| overweight with gestational diabetes | BMI 25 - 29.9; impaired glucose tolerance |
| |
| obese without gestational diabetes | BMI >= 30; normal glucose tolerance |
| |
| obese with gestational diabetes | BMI >= 30; impaired glucose tolerance |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| no intervention | Other | no intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| Activity of Wnt signaling pathway in placental tissue | Analysis of components of the Wnt signaling pathway; like LRP6 receptor, beta-Catenin, GSK3beta, Wnt ligands (=proteins of interest) and an appropriate protein for normalization. Total protein lysates of placental tissue will be used. Analysis will be performed by western blotting and subsequent densitometric analysis. Outcome measure will be [relative protein level of protein or interest/relative protein level of normalization protein]. | through study completion, about 4 years in total |
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Inclusion Criteria:
Exclusion Criteria:
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pregnant women
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Obstetrics deptartment of a University Hospital
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| Name | Affiliation | Role |
|---|---|---|
| Sarah Appel, Dr. | Universitätsklinikum Köln | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Cologne | Cologne | North Rhine-Westphalia | 50931 | Germany |
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| ID | Term |
|---|---|
| D000079262 | Pregnancy in Obesity |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D009765 | Obesity |
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placenta tissue, maternal blood (plasma, serum, EDTA-blood), umbilical cord blood (plasma, EDTA-blood).
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |