Introduction: This study aimed to compare postoperative pain rates following sodium hypochlorite (NaOCl) and KTP laser-assisted pulpotomy treatments in permanent teeth with deep caries, and symptomatic irreversible pulpitis. Methods: Ninety patients complaining of permanent teeth pain due to symptomatic irreversible pulpitis were randomly divided into 3 equal groups. Preoperative pain levels were recorded. After the initial bleeding control was achieved with saline, complete hemostasis was achieved by applying saline (control group), 2.5% NaOCl, or KTP laser according to randomly determined patient groups. Patients were asked to mark their pain level on the visual pain scale at the 6th, 24th, 48th, and 72nd hours, and 7th and 30th days depending on the severity of the pain. The permanent restoration was completed after 7 days. Results: According to the present study, the statistical difference between the groups in terms of preoperative pain and percussion pain levels was insignificant.

There was no significant difference between the groups in terms of demographic data. The postoperative pain level of the KTP laser group was significantly lower at the 6th hour compared to the saline group. There was no significant difference between the groups in terms of postoperative pain level at other time intervals. The greatest pain scores occurred in all groups at 6th hour. Conclusions: KTP laser can be preferred primarily in reducing postoperative pain in pulpotomy treatments. KTP laser or NaOCl assisted pulpotomy can be an effective treatment for pain reduction in permanent teeth with symptomatic irreversible pulpitis.

Inclusion Criteria:

• The patient should be ≥ 18 years old, a single tooth in every patient
• Must be signs of irreversible pulpitis, such as persistent pain that begins spontaneously and/or is exacerbated by cold. This situation should be repeated with the cold test.
• Irreversible pulpitis diagnosed, with or without symptomatic apical periodontitis
• No systemic disease
• Should give a positive response to electrical and thermal tests
• Must be the opposite tooth.
• The tooth is restorable, probing pocket (3mm) depth, and mobility are within normal limits

Exclusion Criteria:

• Presence of allergies
• Using analgesics in the last 12 hours or antibiotics in the last 1 week before the procedure.
• Presence of swelling, palpation pain or sinus tract before treatment, root fracture or crack.
• Failure to control bleeding within 6 minutes,
• Presence of bruxism or open apex.
• Insufficient bleeding after pulp exposure
• Observation of advanced canal calcification
• Presence of internal or external root resorption.