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| Name | Class |
|---|---|
| Horizon 2020 - European Commission | OTHER |
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The main aim of this study is to investigate the effects of cone-modulated light emitted from a visual display on human circadian physiology and cognitive performance in the evening.
The investigators will generate single/multiple cone-isolating contrasts with equivalent stimuli for other cones and melanopsin photoreceptors. The investigators will assess melatonin suppression under three different light scenarios generated using the method of silent substitution by tuning the spectral composition of the light primaries (e.g. LEDs) such that a single target photoreceptor class is maximally stimulated compared to an equal stimulation of the remaining photoreceptors. Additionally, The investigators will examine pupil response, subjective sleepiness, psychomotor vigilance, visual comfort, and skin temperature under three different light scenarios. This allows for new insights into the lights' cone-contribution mechanism to neuroendocrine physiology in the human retina.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Placebo Comparator | Dim light condition as a baseline |
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| Modulation | Active Comparator | Flickering light will be added sinusoidally onto the background light. |
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| Background | Sham Comparator | Constant light with maximum half irradiance (50%) of all primaries. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Flickering light stimuli | Other | The intervention will be exposed to flickering lights (≤200 lux). More specifically, the participants will be asked to be exposed to a specified flickering light (1Hz, 30 seconds On, and 30 seconds OFF) for 2 hours starting at their habitual bedtime (HBT). |
| Measure | Description | Time Frame |
|---|---|---|
| Melatonin concentration | The saliva samples will be collected from participants every 30 min. The investigators hypothesize that the cone flickering light stimuli will have a different melatonin-attenuating effect than the constant background stimuli and that both will have a different effect than baseline. | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Vigilance performance | Sustained attention performance will be assessed throughout the study, using an auditory psychomotor vigilance test (PVT) approach. The investigators hypothesize that the flickering light stimuli will produce different reaction times as measured with the PVT than constant light and baseline. Besides, the baseline will not yield the same reaction times as constant background light. |
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Inclusion Criteria:
Exclusion Criteria:
Exclusion criteria due to study requirements:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fatemeh Fazlali, MSc | Contact | +41(0) 61 325 5478 | fatemeh.fazlali@unibas.ch | |
| Christian Cajochen, Prof | Contact | +41(0) 61 325 5318 | Christian.Cajochen@upk.ch |
| Name | Affiliation | Role |
|---|---|---|
| Christian Cajochen, Prof | Centre for Chronobiology, UPK, University of Basel | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre for Chronobiology | Basel | 4002 | Switzerland |
As the investigators have a plan to submit the study to a registered report journal. The investigators would prefer to share the data after submission.
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| ID | Term |
|---|---|
| C000726607 | photopsia |
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| Constant light stimuli | Other | The intervention will be exposed to constant background lights (≤200 lux). The participants will be asked to be exposed to a specified constant light for 2 hours starting at their habitual bedtime (HBT). |
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| Dim light | Other | This light condition is the baseline (≤10 lux). |
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| 1 year |
| Subjective sleepiness | The investigators will collect subjective sleepiness ratings using the one-question 9-point Karolinska Sleepiness Scale. The investigators hypothesize that sleepiness (ratings) will be different in the flickering light stimuli than in the constant background light and both will be different than baseline. | 1 year |
| Visual comfort | To assess each participant's subjective perception of visual comfort, The investigators will use a custom 7-point rating scale that probes brightness, light color, and glare perception based on a selection of questions. The investigators hypothesize that visual discomfort ratings will change in the flickering light stimuli in comparison to the constant background stimuli and baseline. | 1 year |
| Skin temperature | The investigators will monitor skin temperatures using six surface temperature thermocouples (BS 1922L Thermochron iButton®, Maxim, US) placed on proximal and distal regions of the body surface. The investigators hypothesize that the temperature of the body skin will be different in the flickering light stimuli than in the constant stimuli and both will have a different effect in comparison to the baseline. | 1 year |
| Pupil response | The investigators will measure changes in the pupil area using a silent substitution Pupillograph. The investigators hypothesize that the pupil constriction will be different after exposure to the light conditions as cones and post-receptoral channels adapt to the light stimuli. Besides, the pupil constriction will change differently under the cone-modulated light when the direction of stimuli is identical to the direction of flickering light condition. | 1 year |