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| Name | Class |
|---|---|
| Ministry of Education, Singapore | OTHER_GOV |
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The purpose of this study is to assess the glycaemic controlling effects of BSG and bio-transformed BSG-containing biscuits in Singapore adults with MetS. The investigators hypothesized that consumption of BSG and bio-transformed BSG containing biscuit will improve glycaemic control.
This is a double-blind, randomised, crossover experiment. During the 3-week, 19 subjects will participate in a 3 meal tolerance test (MTT). During each MTT session, all subjects are required to consume 90 g biscuits (either control, autoclaved BSG or bio-transformed BSG biscuits) and monitored over a period of 240 minutes. All three types of biscuits will be consumed at a randomised sequence during this 3-week period. Post-prandial blood glucose, insulin, lipid and amino acid responses, breath analysis, body composition, blood pressure, appetite assessment, and any other glycaemic biomarkers will be assessed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control biscuits group | Placebo Comparator | For each MTT, subjects are to consume 90 g control biscuits as their breakfast within 15 mins. |
|
| autoclaved BSG-containing group | Experimental | For each MTT, subjects are to consume 90 g autoclaved BSG-containing biscuits as their breakfast within 15 mins. |
|
| bio-transformed BSG-containing group | Experimental | For each MTT, subjects are to consume 90 g bio-transformed BSG-containing biscuits as their breakfast within 15 mins. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| autoclaved BSG-containing biscuits | Dietary Supplement | Consumption of autoclaved BSG-containing biscuits as breakfast. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in blood glucose concentration | Glucose concentration in the blood will be measured | Every week (week 1, week 2 and week 3) |
| Change in blood insulin concentration | Insulin concentration in the blood will be measured | Every week (week 1, week 2 and week 3) |
| Change in blood triglyceride concentration | Triglyceride concentration in the blood will be measured | Every week (week 1, week 2 and week 3) |
| Change in blood cholesterol concentration | Total cholesterol concentration in the blood will be measured | Every week (week 1, week 2 and week 3) |
| Change in blood Low-density Lipoprotein-cholesterol (LDL) concentration | Low-density Lipoprotein-cholesterol concentration in the blood will be measured | Every week (week 1, week 2 and week 3) |
| Change in High-density Lipoprotein-cholesterol (HDL) concentration | High-density Lipoprotein-cholesterol concentration in the blood will be measured | Every week (week 1, week 2 and week 3) |
| Change in blood amino acid concentration | Amino acid concentration in the blood will be measured | Every week (week 1, week 2 and week 3) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in appetite assessed by visual analogue scale | Visual analogue scale will be used to assess appetite. | Every week (week 1, week 2 and week 3) |
| Change in breath CH4 and H2 concentrations |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jung Eun Kim | Food Science and technology, Faculty of Science, National University of Singapore | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yujing Xu | Singapore | 117543 | Singapore |
Electronic copies of the data with identifiable participant information will be kept on a secure website with access limited to Dr. Kim and Dr. Kim's research staff. All data will be de-identified prior to statistical analyses.
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| bio-transformed BSG-containing biscuits | Dietary Supplement | Consumption of bio-transformed BSG-containing biscuits as breakfast. |
|
| control biscuits | Dietary Supplement | Consumption of plain biscuits as breakfast. |
|
CH4 and H2 concentrations will be measured by breath analyzer
| Every week (week 1, week 2 and week 3) |
| Change in weight and height | Weight (in kilograms) and height (in meters) will be combined to report BMI in kg/m^2 | Every week (week 1, week 2 and week 3) |
| Change in waist circumference | Waist circumference (in cm) will be measured | Every week (week 1, week 2 and week 3) |
| Change in blood pressure | Systolic and diastolic blood pressure (in mmHg) will be measured by a blood pressure monitor. | Every week (week 1, week 2 and week 3) |
| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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