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Optimizing fluid therapy is one of the main concerns for anesthesiologists during the intraoperative period. It becomes even more important in high-risk long lasting surgeries as pancreaticoduodenectomy. Therefore evaluating fluid responsiveness prior to fluid loading is highly recommended. To the best of our knowledge there is no study comparing the abilities short time low PEEP challenge and mini fluid challenge in predicting fluid responsiveness.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients Undergoing Pancreaticoduodenectomy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fluid Loading | Other | Hemodynamic and ventilatory parameters will be recorded at five time points (T1 - T5). After baseline meausrements (T1), additional 5 cmH2O PEEP will be applied to patients for 30 seconds (short time low peep challenge, SLPC). Prior to PEEP lowering T2 measurement will be performed. T3 measurement will be performed one minute after PEEP is decreased to its initial value and will be recorded as the second baseline. Thereafter, 100 ml isotonic saline will be infused over one minute (MFC). T4 measurement will be performed one minute after MFC is completed,. Lastly, T5 measurement will be performed three minutes after additional 400 ml of isotonic saline is infused within 10 minutes to complete 500 ml of fluid loading. |
| Measure | Description | Time Frame |
|---|---|---|
| Difference between the abilities of two methods to predict fluid responsiveness defined as an increase in stroke volume index >15% after fluid loading | Difference between the area under reciever operating characterisitcs curve of two methods | one day |
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Inclusion Criteria:
Exclusion Criteria:
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Patients undergoing pancreaticoduodenectomy
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Başakşehir Çam adn Sakura City Hospital | Istanbul | Turkey (Türkiye) | ||||
| Başakşehir Çam and Sakura City Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38946384 | Derived | Abdullah T, Gokduman HC, Bahar Ozbey N, Sarban O, Ali A, Gumus Ozcan F. Comparison of the ability of short time low PEEP challenge and mini fluid challenge to predict fluid responsiveness in patients undergoing open pancreaticoduodenectomy: an observational cohort study. Eur Rev Med Pharmacol Sci. 2024 Jun;28(12):3860-3870. doi: 10.26355/eurrev_202406_36463. |
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| Istanbul |
| Turkey (Türkiye) |