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The objectives of this study to explore whether acupuncture can improve the psychoneurological symptom cluster (pain, fatigue, sleep disturbance) in survivors of breast cancer and explore biomarker changes after the acupuncture intervention. Acupuncture treatments will be provided to breast cancer survivors twice weekly for 5 weeks.
The investigators will conduct the study with early stage breast cancer survivors who have completed their primary cancer treatment. They will all receive acupuncture. Treatments will be twice weekly for 5 weeks, for 30 minutes per treatment. At baseline and post-treatment, subjects will be collected blood and stool samples, complete symptom questionnaires that measure pain, fatigue, and sleep disturbance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acupuncture | Experimental | All subjects will receive active acupuncture. The acupuncture intervention will consist of 10 acupuncture sessions, twice weekly for 5 weeks. There will be at least 1 day in between session. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acupuncture | Other | All participants will receive a semi-standardized acupuncture protocol (standardized points for pain, fatigue, depression, anxiety, sleep disturbance, with additional points for patient's particular pain location) |
| Measure | Description | Time Frame |
|---|---|---|
| PROMIS Pain Interference | Scores range from 4-20; higher scores indicate that pain is interfering with daily activities more | After 10th acupuncture treatment, at 6 weeks post-baseline (study completion) |
| PROMIS Fatigue | Scores range from 4-20; higher scores indicate that severe fatigue | After 10th acupuncture treatment, at 6 weeks post-baseline (study completion) |
| PROMIS Sleep Disturbance | Scores range from 4-20; higher scores indicate that severe sleep disturbance | After 10th acupuncture treatment, at 6 weeks post-baseline (study completion) |
| Measure | Description | Time Frame |
|---|---|---|
| PROMIS Depression | Scores range from 4-20; higher scores indicate that severe depression | After 10th acupuncture treatment, at 6 weeks post-baseline (study completion) |
| PROMIS Anxiety | Scores range from 4-20; higher scores indicate that severe anxiety |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Illinois at Chicago College of Nursing | Chicago | Illinois | 60612 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41685420 | Derived | Li H, Gao S, Schlaeger JM, Choi H, Xia Y, Sun J, Doorenbos AZ. Changes in Glutathione Metabolites and Reactive Oxygen Species from Baseline to Post-Treatment in Breast Cancer Survivors with Psychoneurological Symptoms Receiving Acupuncture. Integr Cancer Ther. 2026 Jan-Dec;25:15347354251411913. doi: 10.1177/15347354251411913. Epub 2026 Feb 13. |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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| ID | Term |
|---|---|
| D015670 | Acupuncture Therapy |
| ID | Term |
|---|---|
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
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| After 10th acupuncture treatment, at 6 weeks post-baseline (study completion) |
| D017437 |
| Skin and Connective Tissue Diseases |