Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Hantaviruses are emerging pathogens responsible for hemorrhagic fever with renal syndrome. Severity risks factors aren't consensual in litterature, mostly related to scandinavian cohorts. A prognostic score was created to help patient's orientation in healthcare system but wasn't independantly validated (Hentzien, Emerging infectious diseases 2018).
This retrospective cohort of hantavirus infected hospitalized adults patients in the north-eastern quarter of France between 2013 and 2022 will specify the kidney damage during infection and risk factors for a severe form (defined par acute kidney injury KDIGO 3). The previous prognostic score performance will be evaluated in this cohort.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HANTA-NE | All adult patient hospitalized for hantavirus infection between 01/01/2013 and 31/12/2022 in North Eastern France |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| HANTA-NE | Other | Observational cohort study |
|
| Measure | Description | Time Frame |
|---|---|---|
| Creatinin level | Acute Kidney injury KDIGO 3 | Through study completion, an average of 2 years |
| Hemorrhagic syndrome | Major bleeding requiring blood transfusion | Through study completion, an average of 2 years |
| Death | Death | Through study completion, an average of 2 years |
| Hospitalisation in intensive care unit | Hospitalisation in intensive care unit | Through study completion, an average of 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Score performance to predict severity | Correlation between severity predicted by the score and bio-clinical severity during hospitalization. Score composition : Hematuria = 7 Visual disorders = 8 Leucocyte count > 10 x 10^9 cells/L = 9 Nephrotoxic drug exposure (NSAID, iodinated contrast media, diuretics, renin angiotensin aldosterone system inhibitors, aminoglycosides, glycopeptides) = 10 Thrombocytopenia < or = 90 000/mm3 = 11 Risk group according score scale 0-10 Low risk 11-19 intermediate risk 20-45 high risk |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
All adults patient hospitalized for hantavirus infection during study time frame.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Alice CORBEL, M.D. | Central Hospital, Nancy, France | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Central Hospital | Nancy | 54000 | France |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D018778 | Hantavirus Infections |
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D002044 | Bunyaviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D007239 | Infections |
Not provided
Not provided
Not provided
Not provided
Not provided
| Through study completion, an average of 2 years |
| Hypotension | Lowest systolic blood presure during hospitalisation < 90mmHg | Through study completion, an average of 2 years |
| Proteinuria | Proteinuria during hospitalisation defined by proteinuria/creatininuria above 500 mg/g or equivalent | Through study completion,an average of 2 years |
| Urinary dipstick | Leucocyturia or hematuria | Through study completion, an average of 2 years |
| ALAT, ASAT | Liver cytolysis | Through study completion, an average of 2 years |
| calcium | hypocalcemia, hypercalcemia | Through study completion, an average of 2 years |
| phosphorus | hypophaspahtaemia, hyperphasphatemia | Through study completion, an average of 2 years |
| potassium | hypokaliemia, hyperkaliemia | Through study completion, an average of 2 years |
| sodium | blood sodium level disorders | Through study completion, an average of 2 years |
| bicarbonate blood level | metabolic acidosis, metabolic alcalosis | Through study completion, an average of 2 years |
| Heamoglobin | Anemia | Through study completion, an average of 2 years |
| platelets level | thrombocytemia | Through study completion, an average of 2 years |
| Urine output | Polyruria above 3 L/day | Through study completion, an average of 2 years |
| D051437 |
| Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |