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The anatomical characteristics of veins and venous sinus result in great differences between cerebral venous system diseases and cerebral artery diseases in etiology, pathophysiology and clinical features.Therefore, understanding the anatomy and variation of normal venous sinuses is essential to identify the intracranial venous lesions.
The classification of venous sinus and its variation based on the autopsy of patients can not fully reflect the real anatomy and variation of venous sinus in human, and the targeted research on healthy people is still unknown. The main purpose of this research is to use multimodal magnetic resonance technology to study the variation of venous sinus in Chinese healthy population, to preliminarily improve the anatomical classification of venous sinus in Chinese , to verify the the correlation between venous sinus variation and various non-genetic factors at the same time, as well as establishing reliable quantitative evaluation indicators.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| anotomy and variation of venous sinus | Diagnostic Test | Contrast enhanced-magnatic resonance venography(CE-MRV)and other magnetic resonance imaging methods are used to estimate the anatomy of cerebral venous sinus. | ||
| the level of biomarker in bood | Diagnostic Test | Elisa or omics analysis is used to test the level of biomarker in blood. |
| Measure | Description | Time Frame |
|---|---|---|
| The anotomy and variation of venous sinus in Chinese healthy individuals | According to the connection types of superior sagittal sinus and transverse sinus at the the torcular Herophili assessed with contrast-enhanced MR venography and phase-contrast MR venography, describe the anatomical classification of venous sinus based on the anatomical descriptions of Osborn and describe the anatomical variations that are not included in the existing classification. Calculating the proportion of each type. | On the day of examination |
| Measure | Description | Time Frame |
|---|---|---|
| The diameters of venous sinus and small veins in Chinese healthy individuals | Measuring the diameters of venous sinus and small veins assessed with contrast-enhanced MR venography | On the day of examination |
| Serum biomarkers in Chinese healthy individuals |
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Inclusion Criteria:
Exclusion Criteria:
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Chinese healthy individuals aged 18-35 years without clinical symtoms and cerebral venous diseases
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xunming Ji, MD.PhD | Contact | 010-83199430 | jixm@ccmu.edu.cn | |
| Lu Liu, MD | Contact | 13370186128 | bingtangjiaozi@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Xunming Ji, MD.PhD | Xuanwu Hospital, Beijing | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xuanwu hospital;Capital Medical University | Recruiting | Beijin | XI Cheng District | 100053 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28494642 | Background | Cheng Y, Li WA, Fan X, Li X, Chen J, Wu Y, Meng R, Ji X. Normal anatomy and variations in the confluence of sinuses using digital subtraction angiography. Neurol Res. 2017 Jun;39(6):509-515. doi: 10.1080/01616412.2017.1323383. Epub 2017 May 11. |
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| ID | Term |
|---|---|
| D012851 | Sinus Thrombosis, Intracranial |
| ID | Term |
|---|---|
| D020767 | Intracranial Thrombosis |
| D002542 | Intracranial Embolism and Thrombosis |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
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Blood samples from enrolled participants are drawn by nurse using containing coagulant tubes.
The level of biomarkers are detected using Elisa or omics analysis |
| On the day of examination |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D013923 | Thromboembolism |
| D016769 | Embolism and Thrombosis |