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Recently, a study showed that markers of neutrophil extracellular traps formation, a mechanism corresponding to neutrophil activation, were increased in patients who died of COVID 19 compared with survivors.
The investigators propose to analyze the NEU-SFL parameter, obtained automatically on the Sysmex™ blood count machine (Sysmex Corporation, Kobe, Japan) and which is considered as a reflect of neutrophil extracellular traps formation, in these two groups of patients. The aim was to evaluate whether this parameter could be used to predict the risk of death related to COVID 19.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| COVID-19 survivors | Patients hospitalized at Nimes university hospital in 2021 for COVID-19 who survived. | ||
| COVID-19 Deceased | Patients hospitalized at Nimes university hospital in 2021 for COVID-19 who died. |
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| Measure | Description | Time Frame |
|---|---|---|
| To compare the rate of NEU-SFL in patients hospitalized at Nimes hospital for COVID-19 in 2021, according they survived or not. | Data collection | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Compare the rate of NEU-SFL in patients hospitalized at Nimes hospital for COVID-19 in 2021 who survived, between entry and discharge from Nimes hospital | Data collection | 3 months |
| Compare the rate of NEU-SFL in patients hospitalized at Nimes hospital for COVID-19 in 2021 who died, between entry and discharge from Nimes hospital |
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Inclusion Criteria:
Exclusion Criteria:
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All adult patients hospitalized for COVID-19 at Nimes Hospital in 2021.
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| Name | Affiliation | Role |
|---|---|---|
| Anissa MEGZARI | CHU Nimes | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Nimes | Nîmes | 30029 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36619613 | Result | Fortier M, Chea M, Ain C, Loyens M, Boudemaghe T, Gris JC, Bouvier S. Direct blood fluorescence signal intensity of neutrophils (NEU-SFL): A predictive marker of death in hospitalized COVID-19 patients? Front Med (Lausanne). 2022 Dec 21;9:1062112. doi: 10.3389/fmed.2022.1062112. eCollection 2022. |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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Data collection |
| 3 months |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |