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Some studies suggest that specific chiropractic care (techniques known as "spinal manipulation therapy") can have benefits to the immune system but studies are scarce, sample sizes small, and methodology and analyses often not of the highest scientific standards. The investigators will example how 36 sessions of chiropractic care over 9-12 weeks can impact immune cell function using a randomized clinical trial design.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention | Experimental | experimental group will receive 36 chiropractic treatments designed to correct vertebral subluxation over ~12 weeks |
|
| waitlist control | No Intervention | waitlist control will receive no chiropractic interventions and will be reminded that to successfully complete their condition, they do not seek alternative chiropractic treatments |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| full spine corrective protocol | Procedure | 36 chiropractic adjustments over 12 weeks (3 visits per week) with in office spinal traction on the 3D Denneroll Traction Table, as well as supplemental home exercises |
| Measure | Description | Time Frame |
|---|---|---|
| Change in CD25+ Regulatory T Cell | CD25+ Regulatory T Cell count will be measured by surface staining using flow cytometry | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change in CD4+ and CD8+ T cell | CD4+ and CD8+ T cell count measured by surface staining using flow cytometry | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in TNF alpha secretion | Ex-vivo whole blood culture for either 4 hours in LPS or 24 hours in Poly I:C. | 12 weeks |
| Changes in IFN gamma secretion | Ex-vivo whole blood culture for either 4 hours in LPS or 24 hours in Poly I:C. |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of British Columbia Okanagan | Kelowna | British Columbia | V1V 1V7 | Canada |
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parallel-arm randomized control trial
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| 12 weeks |
| Change in body mass | Body mass in kilograms will be measured by a scale | 12 weeks |
| Change in Blood Pressure | Manual blood pressure (systolic and diastolic) in millimetres mercury assessed in the clinic | 12 weeks |
| Change in vertebral subluxation | Absolute rotation angle (ARA) of the cervical spine assessed by X-ray | 12 weeks |
| Quality of Life Assessment | Differences in quality of life as measured via Oswestry | 12 weeks |
| Quality of Life Assessment | Differences in quality of life as measured via SF36 | 12 weeks |
| Quality of Life Assessment | Differences in quality of life as measured via Neck Disability Index. | 12 weeks |
| Change in Posture | Posture analysis as measured by JTech Digital Inclinometer | 12 weeks |