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The aim of this study is compare the efficacy of local anesthetic infiltration into all layers of the anterior abdominal wall and peritoneal instillation and intrathecal injection of morphine with local anesthesic to reduce pain in women undergoing elective cesarean section under spinal anesthesia. The primary outcome is to compare the total amount of opioids consumed in the first 24 hours postoperatively.
Secondary purpose; Pain scores at 2,4,6,12,and 24 hours during movement ( moving back and forth in bed ) and rest ( lying motionless in bed )
This prospective randomized double-blind study will be planned on 46 pregnant women aged 18-50 who will undergo cesarean section with Pfannenstiel incision under spinal anesthesia with American Society of Anesthesiologists Classification (ASA) II,fullterm singular pregnancy after receiving the approval of the ethics committee of Ataturk University Medical Faculty Hospital and written approval of the patients
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group intraperitoneal instillation of local anesthetic + local anesthetic infiltration (IPLA+ LWI) | Active Comparator | local anesthetic infiltration into all layers of the anterior abdominal wall and peritoneal instillation |
|
| Group morphine ( M ) | Active Comparator | intrathecal injection of morphine with local anesthesic |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Morphine hydrochloride | Drug | Group M will be given a 0.5% Bupivacain Dosage Regimen with weight and height adjustment+15 μg fentanyl +150 μg morphine intrathecally. |
|
| Measure | Description | Time Frame |
|---|---|---|
| The primary outcome is to compare the total amount of opioids consumed in the first 24 hours postoperatively. | The primary outcome is to compare the total amount of opioids consumed in the first 24 hours postoperatively. | postoperative 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Visual Analog Scale (VAS) (0-10) at 2,4,6,12 and 24 hours postoperatively | The VAS is a validated.Possible scores range from 0 (no pain) to 10 (worst possible pain) | 2,4,6,12,and 24 hours postoperatively |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| ayÅŸenur dostbil, prof | Department of Anesthesiology and Reanimation.Ataturk Universty School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Atatürk üniversty medicine school | Erzurum | YAKUTİYE | 25100 | Turkey (Türkiye) |
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| ID | Term |
|---|---|
| D000377 | Agnosia |
| ID | Term |
|---|---|
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| D005283 | Fentanyl |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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|
| Bupivacain | Drug | Group LWI+IPLA will given 30 ml %0,5 bupivacaine+%2 lidocaine infiltration and instillation |
|
|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D000588 |
| Amines |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |