Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Estrie University Integrated Health and Social Services Center - University Hospital of Sherbrooke | OTHER |
Not provided
Not provided
Not provided
Not provided
The combination of data from different origins (biological, health, patient-related) has the potential to improve care for the elderly. Precision approaches that are emerging in health are based on the premise that a better understanding of the biological responses to interventions will make it possible to optimize the treatments. In the field of exercise, this type of approach is emerging. This pilot study aims to collect preliminary data to demonstrate that a patient-centric vision with data from multiple sources is mandatory to personalize exercise intervention and improve health care. Older adults with end-stage chronic disease treated by hemodialysis represent a population of choice that requires personalized care since they are multimorbid and exhibit a complex health profile.
On the other hand, the beneficial effects of exercise are still little understood and the avoidance of adverse effects in response to exercise such as hypotension during dialysis remains uninvestigated.Objective: Demonstrate the feasibility of an integrative approach by combining "omics", clinical data, patient-related outcomes (PRO) as well as exercise variables (e.g., intensity, duration) Methods: A total of 10 people aged 60 and over will be recruited to randomly perform 2 experimental conditions: hemodialysis alone (CONT) or hemodialysis + aerobic exercise (EX), which will be carried out over 2 visits one week apart. These visits will take place at the scheduled time of the hemodialysis treatment. The variables of interest are: blood pressure response to a single bout of exercise exercise (during and post-exercise), symptoms (with visual analogue scales within 36 hours of the visit + Dialysis symptom index for the 7 days after the experimental visit), dialysis efficiency (Kt/V) and biological response (proteomics and metabolomics). Health-related quality of life (KDQOL questionnaire), medical data (electronic medical record), and level of physical activity (PASE questionnaire and smart watch; Apple Watch) will be evaluated.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Aerobic intradialytic exercise | Experimental | 10 patients will perform Aerobic exercise with the cycle ergometer prototype (EXALT) during hemodialysis |
|
| Standard care | Experimental | 10 patients will receive hemodialysis treatment (usual care) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aerobic exercise | Other | EX: 30 min of aerobic exercise (3/10 Borg scale) during hemodialysis treatment (between 30 min and 3h of treatment). |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in blood pressure | Measured using standard clinical procedures (Automatic Blood Pressure Monitor at rest and with aneroid sphygmomanometer during and after exercise) | Before and after the condition as well as every 5 minutes during the 20 minutes after (10 measurements). After this time frame, each 30 minutes up to the end of the dialysis session. |
| Change in perceived fatigue | 10-centimeter horizontal visual analog scale, going from no fatigue (left) to extreme fatigue (right) | Measured at 2:00 pm and 6:00 pm the day of the experimental condition and at 10:00 am, 2:00 pm and 6:00 pm the day following the experimental condition (for a total of 24 hours). |
| Change in perceived sleepiness | 10-centimeter horizontal visual analog scale, going from no sleepiness (left) to extreme sleepiness (right) | Measured at 2:00 pm and 6:00 pm the day of the experimental condition and at 10:00 am, 2:00 pm and 6:00 pm the day following the experimental condition (for a total of 24 hours). |
| Change in mood | 10-centimeter horizontal visual analog scale, going from very bad (left) to very good (right) | Measured at 2:00 pm and 6:00 pm the day of the experimental condition and at 10:00 am, 2:00 pm and 6:00 pm the day following the experimental condition (for a total of 24 hours). |
| Change in perceived soreness | 10-centimeter horizontal visual analog scale, going from no soreness (left) to extreme soreness (right) | Measured at 2:00 pm and 6:00 pm the day of the experimental condition and at 10:00 am, 2:00 pm and 6:00 pm the day following the experimental condition (for a total of 24 hours). |
| Measure | Description | Time Frame |
|---|---|---|
| Hematocrit (%) | Routinely measured (monthly) as standard clinical practice, before a dialysis session. | Extracted from each patient's medical record at inclusion. |
| Hemoglobin (g/L) | Routinely measured (monthly) as standard clinical practice, before a dialysis session. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre de recherche sur le vieillissement | Sherbrooke | Quebec | J1H 4C4 | Canada | ||
| CIUSSS de l'Estrie - CHUS |
Waiting for the University policy - standard operating procedures and data (upon ethics approval) would be available upon reasonable request
Not provided
Not provided
Not provided
Not provided
Not provided
Each participant performed 2 experimental conditions (rest, moderate continuous aerobic exercise with our cycle ergometer prototype - EXALT).
Not provided
Not provided
Not provided
Not provided
| Control | Other | CONT: participants will receive hemodialysis treatment only (usual care) |
|
| Change in perceived sleep quality |
10-centimeter horizontal visual analog scale, going from very bad (left) to extreme soreness (right) |
| Measured at 10:00 am the day following the experimental condition. |
| Plasma Metabolome and proteome at the end of the experimental (exercise) condition | A blood draw will be realized immediately at the end of the dialysis session comprising the exercise condition. The plasma metabolome and proteome will be determined using mass spectrometry. | After 30 minutes of exercise |
| Plasma Metabolome and proteome at the end of the control (rest) condition | A blood draw will be realized immediately at the end of the dialysis session representing the control condition. The plasma metabolome and proteome will be determined using mass spectrometry. | After 30 minutes of rest |
| Single pool Kt/V, experimental (exercise) condition | measured using standard clinical procedures (blood draw before and at the end of the dialysis session comprising the exercise condition, by a research nurse). | After 4 hours of dialysis |
| Single pool Kt/V, control (rest) condition | measured using standard clinical procedures (blood draw before and at the end of the dialysis session representing the condition, by a research nurse). | After 4 hours of dialysis |
| Extracted from each patient's medical record at inclusion. |
| Red blood cells count (10^12/L) | Routinely measured (monthly) as standard clinical practice, before a dialysis session. | Extracted from each patient's medical record at inclusion. |
| White blood cells count (10^9/L) | Routinely measured (monthly) as standard clinical practice, before a dialysis session. | Extracted from each patient's medical record at inclusion. |
| Platelets count (10^9/L) | Routinely measured (monthly) as standard clinical practice, before a dialysis session. | Extracted from each patient's medical record at inclusion. |
| Red blood cell mean corpuscular hemoglobin (pg) | Routinely measured (monthly) as standard clinical practice, before a dialysis session. | Extracted from each patient's medical record at inclusion. |
| Red blood cell mean corpuscular volume (fL) | Routinely measured (monthly) as standard clinical practice, before a dialysis session. | Extracted from each patient's medical record at inclusion. |
| Red blood cell distribution width (%) | Routinely measured (monthly) as standard clinical practice, before a dialysis session. | Extracted from each patient's medical record at inclusion. |
| Plasma sodium (mmol/L) | Routinely measured (monthly) as standard clinical practice, before a dialysis session. | Extracted from each patient's medical record at inclusion. |
| Plasma potassium (mmol/L) | Routinely measured (monthly) as standard clinical practice, before a dialysis session. | Extracted from each patient's medical record at inclusion. |
| Plasma calcium (mmol/L) | Routinely measured (monthly) as standard clinical practice, before a dialysis session. | Extracted from each patient's medical record at inclusion. |
| Plasma phosphate (mmol/L) | Routinely measured (monthly) as standard clinical practice, before a dialysis session. | Extracted from each patient's medical record at inclusion. |
| Plasma glucose (mmol/L) | Routinely measured (monthly) as standard clinical practice, before a dialysis session. | Extracted from each patient's medical record at inclusion. |
| Plasma creatinine (mmol/L) | Routinely measured (monthly) as standard clinical practice, before a dialysis session. | Extracted from each patient's medical record at inclusion. |
| Health-Related Quality of Life | French version of the Kidney Disease Quality of Life 36 items version 1.3 (KDQOL-36) | Once, at the beginning of the dialysis session comprising the first condition |
| Disease-related symptoms | The French version of the Dialysis Symptom Index, consisting in a seven-day recall questionnaire assessing the presence and intensity of 30 symptoms | Twice, seven days after each experimental conditions |
| Physical activity scale for the Elderly (PASE) questionnaire | Recall questionnaire of the previous week's leisure, occupational and domestic physical activity habits validated in older adults. | Once, at the beginning of the dialysis session comprising the first condition |
| Estimated daily energy expenditure | Wrist-worn accelerometer (Apple Watch) | The watch will be worn during the 24 hours following each experimental condition |
| Sherbrooke |
| Quebec |
| J1H 5N4 |
| Canada |
| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
Not provided
Not provided