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| Name | Class |
|---|---|
| Central South University | OTHER |
| West China Hospital | OTHER |
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Human Assisted Reproductive Technology (ART) has become a very effective and nearly irreplaceable clinical treatment for infertility, helping millions of women achieve fertility. However, ART may still have potential health risks to mothers and offspring. To better research and monitor the efficacy and safety of ART, the investigators established CXARDR based on the real medical data in Reproductive and Genetic Hospital of CITIC-Xiangya, which is the world's largest ART single treatment center. CXARDR covers the ART full-cycle treatment records since the hospital perfected its electronic medical record system in 2016, as well as biological samples from the CITIC-Xiangya Genetic Resource Bank. From the preoperative investigation of ART to the 1-year follow-up of ART offspring, CXARDR provides the details of the whole process of treatment and the follow-up outcomes of ART patients, making up for the gap in the data of reproductive and obstetric institutions. The huge biological samples with clinical information also provide more possibilities for in-depth basic researches in the field of reproduction and genetics.
During the past five years (January 2016 to November 2020), the CXARDR has accumulated data concerning more than 223,000 ART treatment cycles from 120,000 infertile couples. The CXARDR also links more than 180,000 blood samples, 65,000 follicular fluid samples, 80,000 semen samples, and 31,000 granulosa cell samples from 75,000 couples. The data volume is substantial with over 800 variables being documented, and most variables are designed as structured fields. The whole process of data access, data extraction, data processing and data analysis was conducted through a dedicated server inside the CITIC-Xiangya Data Center. All investigators cannot access sensitive information, are required to sign data confidentiality agreement, and need to be approved by the CITIC-Xiangya Ethics Committee.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Infertile couples | Infertile couples who came to the hospital for ART treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Different baseline characteristics and clinical management | Other | Personal history, basic diseases, stimulation plan, type of ART, transplantation strategy, etc. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cleavage rate | The proportion of zygotes that cleave to become embryos on Day 2 (44 ± 1 h post-insemination) . | Up to 3 days after insemination |
| Implantation rate | The number of gestational sacs divided by the total number of embryos transferred, irrespective of whether a pregnancy was established. | Up to 30 days after transplantation |
| Clinical pregnancy | A pregnancy diagnosed by ultrasonographic examination of at least one fetus with a discernible heartbeat. | Up to 30 days after transplantation |
| Miscarriage | The spontaneous loss of an intrauterine pregnancy. | Up to 42 weeks after transplantation |
| Live birth | The complete expulsion or extraction from a woman of a product of fertilization, after 20 completed weeks of gestational age. | Up to 42 weeks after transplantation |
| Gestational age at birth | The age of a fetus is calculated by the best obstetric estimate determined by assessments which may include early ultrasound. | Up to 42 weeks after transplantation |
| Birthweight | Birth weight should be collected within 24 hours of birth and assessed using a calibrated electronic scale with ten-gram resolution. | Up to 42 weeks after transplantation |
| Measure | Description | Time Frame |
|---|---|---|
| Embryo development rate | The proportion of cleaved embryos at the 4-cell stage on Day 2 (44 ± 1 h post-insemination) or at the 8-cell stage on Day 3 (68 ± 1 h post-insemination) per normally fertilized oocyte. | Up to 3 days after insemination |
| 1PN rate |
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Inclusion Criteria:
Exclusion Criteria:
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Infertile couples who received ART treatment in our hospital (CITIC-Xiangya).
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| Name | Affiliation | Role |
|---|---|---|
| Lin Ge, PhD | Reproductive & Genetic Hospital of CITIC-XIANGYA Changsha, Hunan China | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42388867 | Derived | Hu J, Ma S, Gao Y, Peng Y, Wang X, Wu IXY, Gong F. Elevated triglyceride glucose-body mass index is associated with a higher risk of reduced cumulative live birth and adverse pregnancy outcomes in women undergoing assisted reproductive technology: a retrospective cohort study. Front Endocrinol (Lausanne). 2026 Jun 17;17:1842023. doi: 10.3389/fendo.2026.1842023. eCollection 2026. | |
| 38205885 |
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According to the policy of CITIC-Xiangya Reproductive and Genetic Hospital,research institutions could apply for data access by submitting a formal study protocol, subjected to approval by the hospital academic committee. Ethical review and research registration are mandatory for all studies.
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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blood, semen, follicular fluid and granulosa cell
| Height of offspring 1 year old | Self-measurement | Up to 1 year after delivery |
| Weight of offspring 1 year old | Self-measurement | Up to 1 year after delivery |
The proportion of inseminated oocytes with one pronucleus on Day 1 (17 ± 1 h post-insemination). |
| Up to 2 days after insemination |
| Blastocyst development rate | The proportion of blastocysts observed at 116 ± 2 h post-insemination as a function of the number of normally fertilized oocytes. | Up to 7 days after insemination |
| Proportion of good blastocysts | The proportion of blastocysts with a grade of "good" or higher. | Up to 7 days after insemination |
| Ectopic pregnancy | A pregnancy outside the uterine cavity, diagnosed by ultrasound, surgical visualization, or histopathology. | Up to 30 days after transplantation |
| Gestational diabetes | By oral glucose tolerance test between 24 and 28 gestational weeks (fasting glucose ≥5.1 mmol/L, 1-h glucose ≥10.0 mmol/L, 2-h glucose ≥8.5 mmol/L; one abnormal result sufficient). | Up to 30 weeks after transplantation |
| Gestational hypertension | Maternal systolic blood pressure ≥ 140 mmHg and (or) diastolic pressure ≥ 90 mmHg. | Up to 42 weeks after transplantation |
| Major congenital anomaly | Structural, functional, and genetic anomalies, that occur during pregnancy, and identified antenatally, at birth, or later in life, and require surgical repair of a defect, or are visually evident, or are life-threatening, or cause death. | Up to 42 weeks after transplantation |
| Neonatal mortality | Death of a live born baby within 28 days of birth. | Up to 30 days after delivery |
| Derived |
| Ma S, Tan J, Xiong Y, Peng Y, Gong F, Hu L, Wang X, Tan L, Liu R, Hocher B, Sun X, Lin G. Cohort Profile: CITIC-Xiangya Assisted Reproductive Technology Cohort (CXART Cohort). Int J Epidemiol. 2024 Feb 1;53(1):dyad188. doi: 10.1093/ije/dyad188. No abstract available. |