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Existing techniques available for capturing reliable aortic pulse wave velocity measurements and estimating aortic stiffness are costly and require technical expertise. The purpose of this research is to investigate an oximeter device performance as a stand-alone aortic pulse wave velocity (PWV) measurement instrument. By validating this device and its measurements against the gold-standard method of carotid-femoral readings, we aim to demonstrate that the proposed method is an comparably effective in terms of the metrics (Mean difference, standard deviation, correlation, etc.) outlined by the Artery Society Guidelines.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Device Calibration & Algorithm Training | The data obtained from this group will be used to a) quantify the relationship between PWV measured at the groin versus the thigh for less intrusive future piezo sensor placement and b) train the proposed device for the next cohort. |
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| Device & Algorithm Testing | The gold-standard and new device values will be collected from this group to validate the previously trained system. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| System & Method for Monitoring Aortic Pulse Wave Velocity & Blood Pressure | Device | Carotid-femoral aortic pulse wave velocity will be compared against values collected from the oximeter system. The former is assessed by placing piezoelectric pressure sensors at three locations: the right common carotid artery, the right common femoral artery (groin), and the right superficial femoral artery (thigh). The oximeter will be secured on the right index finger. Simultaneous data collection will occur for both methods, with each trail lasting 60 seconds. |
| Measure | Description | Time Frame |
|---|---|---|
| Aortic Pulse Wave Velocity | The speed at which a single pulse/heart beat propagates down the aorta. | 6 measurements per subject, each lasting 60 seconds |
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Inclusion Criteria:
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Exclusion Criteria:
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Primary care clinic patients with a health cardiovascular background.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jess Goodman, M.D. | Contact | 416-670-9306 | jess@goiheart.com | |
| Clare Wei | Contact | 289-338-5669 | c53wei@uwaterloo.ca |
| Name | Affiliation | Role |
|---|---|---|
| Jess Goodman, M.D. | VitalSines International Inc. | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12796414 | Background | Safar ME, Levy BI, Struijker-Boudier H. Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases. Circulation. 2003 Jun 10;107(22):2864-9. doi: 10.1161/01.CIR.0000069826.36125.B4. No abstract available. | |
| 12677025 | Background | Laurent S, Katsahian S, Fassot C, Tropeano AI, Gautier I, Laloux B, Boutouyrie P. Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke. 2003 May;34(5):1203-6. doi: 10.1161/01.STR.0000065428.03209.64. Epub 2003 Apr 3. |
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| ID | Term |
|---|---|
| D016503 | Drug Delivery Systems |
| D008722 | Methods |
| D001794 | Blood Pressure |
| ID | Term |
|---|---|
| D004358 | Drug Therapy |
| D013812 | Therapeutics |
| D008919 | Investigative Techniques |
| D055986 | Vital Signs |
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| 22278144 | Background | Van Bortel LM, Laurent S, Boutouyrie P, Chowienczyk P, Cruickshank JK, De Backer T, Filipovsky J, Huybrechts S, Mattace-Raso FU, Protogerou AD, Schillaci G, Segers P, Vermeersch S, Weber T; Artery Society; European Society of Hypertension Working Group on Vascular Structure and Function; European Network for Noninvasive Investigation of Large Arteries. Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J Hypertens. 2012 Mar;30(3):445-8. doi: 10.1097/HJH.0b013e32834fa8b0. |
| 29761092 | Background | Xu SK, Hong XF, Cheng YB, Liu CY, Li Y, Yin B, Wang JG. Validation of a Piezoelectric Sensor Array-Based Device for Measurement of Carotid-Femoral Pulse Wave Velocity: The Philips Prototype. Pulse (Basel). 2018 Mar;5(1-4):161-168. doi: 10.1159/000486317. Epub 2018 Feb 8. |
| 2598428 | Background | Kelly R, Hayward C, Avolio A, O'Rourke M. Noninvasive determination of age-related changes in the human arterial pulse. Circulation. 1989 Dec;80(6):1652-9. doi: 10.1161/01.cir.80.6.1652. |
| 25736440 | Background | Chirinos JA, Segers P, Duprez DA, Brumback L, Bluemke DA, Zamani P, Kronmal R, Vaidya D, Ouyang P, Townsend RR, Jacobs DR Jr. Late systolic central hypertension as a predictor of incident heart failure: the Multi-ethnic Study of Atherosclerosis. J Am Heart Assoc. 2015 Mar 3;4(3):e001335. doi: 10.1161/JAHA.114.001335. |
| 21976274 | Background | Ding FH, Fan WX, Zhang RY, Zhang Q, Li Y, Wang JG. Validation of the noninvasive assessment of central blood pressure by the SphygmoCor and Omron devices against the invasive catheter measurement. Am J Hypertens. 2011 Dec;24(12):1306-11. doi: 10.1038/ajh.2011.145. Epub 2011 Oct 6. |
| 24892879 | Background | Pereira T, Maldonado J, Coutinho R, Cardoso E, Laranjeiro M, Andrade I, Conde J. Invasive validation of the Complior Analyse in the assessment of central artery pressure curves: a methodological study. Blood Press Monit. 2014 Oct;19(5):280-7. doi: 10.1097/MBP.0000000000000058. |
| 32033495 | Background | Wang TW, Lin SF. Wearable Piezoelectric-Based System for Continuous Beat-to-Beat Blood Pressure Measurement. Sensors (Basel). 2020 Feb 5;20(3):851. doi: 10.3390/s20030851. |
| 35300400 | Background | Park J, Seok HS, Kim SS, Shin H. Photoplethysmogram Analysis and Applications: An Integrative Review. Front Physiol. 2022 Mar 1;12:808451. doi: 10.3389/fphys.2021.808451. eCollection 2021. |
| Background | I.B. Wilkinson, C.M. McEniery, G. Schillaci, P. Boutouyrie, P. Segers, A. Donald, et al. ARTERY Society guidelines for validation of non-invasive haemodynamic measurement devices: part 1, arterial pulse wave velocity Artery Res, 4 (2) (2010), p. 34 |
| D010808 |
| Physical Examination |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D006439 | Hemodynamics |
| D002320 | Cardiovascular Physiological Phenomena |
| D002943 | Circulatory and Respiratory Physiological Phenomena |