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Although systemic inflammatory response induced by cardiopulmonary bypass is believed as one of main reasons for these adverse events, the involved mechanism is still unclear.This cohort study would include patients undergoing on-pump valve surgery or CABG. By detecting the changes of immune cell expression profile and inflammatory related substances in blood, the spatiotemporal change curve of immune function of patients is drawn for avoiding or treating adverse events.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Complication group | Postoperative complications are defined as postoperative death, vital organ dysfunction, and mechanical ventilation duration greater than 24 hours.The vital organ dysfunction includes new developed acute kidney injury, long-term low cardiac output, severe liver function injury and neurological function injury. The time of occurrence is defined as from the beginning of surgery to 30 days after surgery or to discharge from hospital. |
| |
| Non-complication group | Patients with none of postoperative complications which showed in Complication group. The time of occurrence is defined as from the beginning of surgery to 30 days after surgery or to discharge from hospital. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| On-pump valve surgery or CABG | Procedure | On-pump valve surgery or coronary arterial bypass grafting |
|
| Measure | Description | Time Frame |
|---|---|---|
| composite outcome | the incidence of vital organ injury, which is defined as a composite measure, including postoperative death, vital organ dysfunction, and mechanical ventilation duration greater than 24 hours. And the vital organ dysfunction includes new kidney injury, long-term low cardiac output, severe liver function injury and neurological function injury. | From the beginning of surgery to 30 days after surgery or to discharge from hospital |
| Measure | Description | Time Frame |
|---|---|---|
| Infection | From the beginning of surgery to 30 days after surgery or to discharge from hospital] | |
| MACCE | including all-cause mortality, myocardial infarction, severe arrhythmias and stroke | From the beginning of surgery to 30 days after surgery or to discharge from hospital] |
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Inclusion Criteria:
Exclusion Criteria:
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Participants are recruited from West China Hospital of Sichuan University who would undergo cardiac surgery under CPB between June 2022 and December 2022
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jing Lin, doctor | Contact | +86 18980605853 | 350576038@qq.com | |
| Tingting Wang, doctor | Contact | +8613606812800 | wangtingting2045@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| West China Hospital of Sichuan University | Recruiting | Chengdu | Sichuan | 610044 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40270561 | Derived | Zheng Y, Ran Y, Wu J, Yang P, Liao X, Zhang J, Meng W, Gou D, Li L, Du L, Lin J. In vitro Validation of a Novel Disposable Remover to Remove Activated Leukocytes Generated During Cardiopulmonary Bypass: A Pilot Study. J Inflamm Res. 2025 Apr 18;18:5355-5370. doi: 10.2147/JIR.S503575. eCollection 2025. |
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| Acute lung injury | Acute onset of bilateral infiltrates on the chest readiograph and hypoxaema(PaO2/Fi O2 ratio <300) in the absence of clincial evidence of left atrial hypertension | From the beginning of surgery to 30 days after surgery or to discharge from hospital] |
| Gastrointestinal complications | including gastrointestinal bleeding and intestinal ischemia | From the beginning of surgery to 30 days after surgery or to discharge from hospital |