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| Name | Class |
|---|---|
| Mibelle AG | INDUSTRY |
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This research aims to explore the potential benefits of supplementation of a natural ingredient, the Monarda didyma extract, to reduce / delay the biological aging of a susceptible population, thus contributing to two relevant topics in science with important social and economic implications: anti-aging strategies for wellness and healthy aging and environmental sustainability using natural products.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Monarda Didyma extract | Experimental | Monarda Didyma extract |
|
| Placebo | Placebo Comparator | Maltodextrin |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Monarda Didyma extract | Dietary Supplement | Monarda Didyma extract; 100 mg/d. 1capsules/day; daily (1 capsule with the lunch) and plenty of water. |
|
| Measure | Description | Time Frame |
|---|---|---|
| DNA methylation age (DNAmAge) | DNA methylation age (years) | 12 weeks |
| Age acceleration (AgeAcc) | Age acceleration as difference between DNA methylation age and chronological age (years) | 12 weeks |
| Leukocyte telomere length (LTL) | Leukocyte telomere length as ratio (T/S) of number telomere repeat sequences (T) to single-copy gene (S) | 12 weeks |
| Mitochondrial DNA copy number (mtDNAcn) | Mitochondrial DNA copy number (mtDNAcn) as ratio (MT/S) of mitochondrial DNA copy number (MT) and the singular copy number of a gene (S) | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Telomerase expression (∆∆Ct) | Telomerase expression as comparative cycle threshold method (∆∆Ct), which compares the difference in cycle threshold values between groups. | 12 weeks |
| Blood pressure |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Azienda Ospedale Università Padova | Padova | PD | 35128 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30301216 | Background | Yao Q, Lin MT, Zhu YD, Xu HL, Zhao YZ. Recent Trends in Potential Therapeutic Applications of the Dietary Flavonoid Didymin. Molecules. 2018 Oct 6;23(10):2547. doi: 10.3390/molecules23102547. | |
| 33182043 | Background | Feng Z, Pang L, Chen S, Pang X, Huang Y, Qiao Q, Wang Y, Vonglorkham S, Huang Q, Lin X, Wei J. Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-kappaB and PI3K/Akt pathways in C57BL/6J mice. Int Immunopharmacol. 2020 Nov;88:107003. doi: 10.1016/j.intimp.2020.107003. Epub 2020 Sep 23. |
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Pilot study; randomized, placebo-controlled, double-blind, parallel design, monocentric.
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| Placebo | Dietary Supplement | Maltodextrin; 100 mg/d. 1capsules/day; daily (1 capsule with the lunch) and plenty of water. |
|
Blood pressure as systolic blood and diastolic blood pressure (mm Hg)
| 12 weeks |
| Salivary cortisol | Salivary cortisol (nmol/L). | 12 weeks |
| Leukocytes | Leukocytes (10^9/L) | 12 weeks |
| erythrocytes | erythrocytes (10^12/L) | 12 weeks |
| hemoglobin | hemoglobin (g/L) | 12 weeks |
| hematocrit | hematocrit (L/L) | 12 weeks |
| MCV mean corpuscular volume | MCV (fL) | 12 weeks |
| MCH mean corpuscular hemoglobin | MCH (pg) | 12 weeks |
| MCHC mean corpuscular hemoglobin concentration | MCHC (g/L) | 12 weeks |
| platelets | platelets (10^9/L) | 12 weeks |
| C reactive protein | C reactive protein - CRP (mg/L) | 12 weeks |
| interleukin 6 | interleukin 6 - IL6 (ng/L) | 12 weeks |
| Questionnaire about Quality of Life: World Health Organization's Quality of Life Assessment BREF version (WHOQOL-BREF) | Domain scores for the WHOQOL-BREF are calculated by taking the mean of all items included in each domain and multiplying by a factor of four. These scores are then transformed to a 0-100 scale, where 100 is the highest and 0 is the lowest QoL. | 12 weeks |
| Questionnaire about sleeping patterns: Pittsburgh Sleep Quality Index (PSQI) | The PSQI contains 19 self-reported combined to form seven "component" scores, each of which has a range of 0 (no difficulty) to 3 (severe difficulty) points. The seven component scores are then added to yield one "global" score, with a range of 0-21 points, "0" indicating no difficulty and "21" indicating severe difficulties in all areas. | 12 weeks |
| Tracking of Hearth Rate using Miband 6 watch | hearth rate as beats per minute (BPM) | 12 weeks |
| Tracking of sleep using Miband 6 watch | sleep (hours) | 12 weeks |
| Tracking of mobility using Miband 6 watch | mobility (step counts) | 12 weeks |
| Total cholesterol | Total cholesterol (mg/dl) | 12 weeks |
| LDL | LDL (mg/dl) | 12 weeks |
| HDL | HDL (mg/dl) | 12 weeks |
| Triglycerides | Triglycerides (mg/dl) | 12 weeks |
| Glycemia | Glycemia (mg/dl) | 12 weeks |
| Insulin | Insulin (mcU/ml) | 12 weeks |
| HOMA | HOMA index - homeostasis model assessment | 12 weeks |
| AST | AST (IU/l) aspartate aminotransferase | 12 weeks |
| SGPT | SGPT (IU/l) Serum Glutamic Pyruvic Transaminase | 12 weeks |
| GGT | GGT (U/l) gamma glutamyl transferase | 12 weeks |
| Creatinine | Creatinine (mg/dl) | 12 weeks |
| Waist | Waist circumference (cm) | 12 weeks |
| Weight | Weight (kg) | 12 weeks |
| Total cholesterol/HDL | Total cholesterol/HDL | 12 weeks |
| LDL/HDL | LDL/HDL cholesterol ratio | 12 weeks |
| 27997902 | Background | Lin X, Bai F, Nie J, Lu S, Lu C, Zhu X, Wei J, Lu Z, Huang Q. Didymin Alleviates Hepatic Fibrosis Through Inhibiting ERK and PI3K/Akt Pathways via Regulation of Raf Kinase Inhibitor Protein. Cell Physiol Biochem. 2016;40(6):1422-1432. doi: 10.1159/000453194. Epub 2016 Dec 20. |
| 31450859 | Background | Pavanello S, Campisi M, Tona F, Lin CD, Iliceto S. Exploring Epigenetic Age in Response to Intensive Relaxing Training: A Pilot Study to Slow Down Biological Age. Int J Environ Res Public Health. 2019 Aug 23;16(17):3074. doi: 10.3390/ijerph16173074. |
| 34368190 | Background | Campisi M, Liviero F, Maestrelli P, Guarnieri G, Pavanello S. DNA Methylation-Based Age Prediction and Telomere Length Reveal an Accelerated Aging in Induced Sputum Cells Compared to Blood Leukocytes: A Pilot Study in COPD Patients. Front Med (Lausanne). 2021 Jul 23;8:690312. doi: 10.3389/fmed.2021.690312. eCollection 2021. |
| 32612244 | Background | Pavanello S, Campisi M, Fabozzo A, Cibin G, Tarzia V, Toscano G, Gerosa G. The biological age of the heart is consistently younger than chronological age. Sci Rep. 2020 Jul 1;10(1):10752. doi: 10.1038/s41598-020-67622-1. |
| 23885040 | Background | Pavanello S, Dioni L, Hoxha M, Fedeli U, Mielzynska-Svach D, Baccarelli AA. Mitochondrial DNA copy number and exposure to polycyclic aromatic hydrocarbons. Cancer Epidemiol Biomarkers Prev. 2013 Oct;22(10):1722-9. doi: 10.1158/1055-9965.EPI-13-0118. Epub 2013 Jul 24. |