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To assess the efficacy and safety of the Ginkgo biloba extract in patients with Knee OA.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ginkgo + standard | Active Comparator | the patients received Ginkgo biloba extract in addition to standard treatment |
|
| placebo + standard | Placebo Comparator | the patients received a placebo in addition to the standard treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ginkgo biloba extract + standard treatment( paracetamol+Diclofenac100mg SR) | Combination Product | 120 mg leaf extract , twice daily in addition to Diclofenac 100 mg Once daily + paracetamol 1g Twice daily |
| Measure | Description | Time Frame |
|---|---|---|
| KOOS score | 42 item questionnaire to assess pain, other symptoms, activities of daily living (ADL), sport and recreation function (Sport/Rec) and knee-related quality of life (QOL). | Changes occured : baseline , 2 weeks , 4 weeks ,and 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| IL-6 | Serum level of interleukin 6 | Changes occured: baseline , 4 weeks,and 8 weeks |
| TNF-alpha | Serum level of tumour necrosis factor - alpha |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Private Clinic | Najaf | N/A (Outside of US) | 00964 | Iraq |
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| ID | Term |
|---|---|
| D020370 | Osteoarthritis, Knee |
| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
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| ID | Term |
|---|---|
| C063170 | Ginkgo biloba extract |
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|
| placebo in addition to the standard treatment | Combination Product | placebo in addition to the standard treatment |
|
| Changes occured: baseline , 4 weeks,and 8 weeks |
| urinary CTX-II | C-terminal telopeptide of type II collagen from urine samples | Changes occured :baseline , 4 weeks,and 8 weeks |
| D012216 |
| Rheumatic Diseases |