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Cubital tunnel syndrome is the second most common compression neuropathy. In severe cases, functional recovery, even with surgery, is often poor. Therefore, alternative adjunct treatments capable of increasing the speed of nerve regeneration are much needed.
The effect of brief conditioning electrical stimulation on nerve regeneration has been showed to be efficacy in animal studies. In this double-blind, randomized, controlled study, the investigators will compare the physiological and functional improvements post surgery compared with the controls who received surgery alone. Because electrical stimulation is reasonably well-tolerated and the treatment only takes an hour, it is a potentially feasible clinical tool for patients with severe nerve injury.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Active Comparator | Control patients will receive cubital tunnel surgery and sham stimulation. |
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| Conditioning electrical stimulation | Experimental | Patients in the stimulation group will receive surgery as well as 1 hour of 20 Hz electrical stimulation 7 days prior to surgery |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Electrical stimulation | Procedure | Patients with cubital tunnel syndrome will receive either surgery and sham stimulation, or conditioning electrical stimulation 7 days prior to surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Motor unit number estimation | A quantitative physiological measure of the number of motor nerve fibres in the target muscle | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Key pinch strength | A functional measure of the ulnar intrinsic hand muscles using a dynamometer | 3 years |
| Disability of the Arm, Shoulder and Hand (DASH) Questionnaire | A questionnaire to quantify the severity of motor and sensory symptoms |
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Inclusion Criteria:
Exclusion Criteria:
1) Patients were excluded if they had concurrent nerve injury, prior surgery for CuTS or coexisting neurologic conditions
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ming Chan | Contact | (780) 492-1614 | Ming.Chan@ualberta.ca |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Alberta | Recruiting | Edmonton | Alberta | T6G 2E1 | Canada |
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| ID | Term |
|---|---|
| D020430 | Cubital Tunnel Syndrome |
| ID | Term |
|---|---|
| D020424 | Ulnar Neuropathies |
| D020422 | Mononeuropathies |
| D010523 | Peripheral Nervous System Diseases |
| D009468 | Neuromuscular Diseases |
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| ID | Term |
|---|---|
| D004558 | Electric Stimulation |
| ID | Term |
|---|---|
| D010812 | Physical Stimulation |
| D008919 | Investigative Techniques |
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Double-blind randomized controlled study
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| 3 years |
| D009422 | Nervous System Diseases |
| D017769 | Ulnar Nerve Compression Syndromes |
| D009408 | Nerve Compression Syndromes |
| D012090 | Cumulative Trauma Disorders |
| D013180 | Sprains and Strains |
| D014947 | Wounds and Injuries |