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Geriatric assessment is now widely used to decide whether older patients with chronic kidney disease should be put on the kidney transplantation waiting list. This study aims to evaluate the association between Geriatric assessment and inscription on kidney transplantation.
There is a high proportion of older patients among patients with kidney failure, raising the question of the access to kidney transplantation within these patients. Geriatric assessment is now widely used to decide whether older patients with chronic kidney disease should be put on the kidney transplantation waiting list.
This study aims to evaluate the association between Geriatric assessment and inscription on kidney transplantation. Secondary objectives includes the analysis of the association between Geriatric assessment and:
It also includes the evolution of Geriatric assessment while still on waiting list and after kidney transplantation.
This study takes place in an University Hospital in Caen, France. This hospital is the only one performing kidney transplantation in the three French departments around. Candidates for kidney transplantation older than 70 years are systematically evaluated by a trained nurse and a geriatrician to perform a comprehensive geriatric assessment, evaluating cognitive functions, risk of fall, nutrition, frailty, functional status, and depressive symptoms. These patients are followed-up each year while still on the waiting list, and once after kidney transplantation. All patients evaluated within this consultation are proposed to enter the study. Patients are excluded in case of refusal or if they are unable to provide informed consent. The inclusion began in January 2019.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Geriatric assessment | Other | Geriatric assessment by a trained nurse and a geriatrician for older kidney transplantation candidates in Caen University Hospital. The geriatric assessment includes a evaluation of cognitive functions, depressive symptoms, risk of fall, nutrition, frailty, and functional status. |
| Measure | Description | Time Frame |
|---|---|---|
| Inscription on kidney transplantation waiting list | Inscription on kidney transplantation waiting list | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Length of hospitalization in the year following kidney transplantation | Units: days | 1 year after kidney transplantation |
| Delayed renal recovery following kidney transplantation | Dialysis requirement during the first week after kidney transplantation |
| Measure | Description | Time Frame |
|---|---|---|
| Evolution of quality of life while on waiting list and after kidney transplantation | Assessed by the SF12 score before and in the year after kidney transplantation | 1 year after kidney transplantation |
| Evolution of cognitive functions while on waiting list and after kidney transplantation |
Inclusion Criteria:
Exclusion Criteria:
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Patients with chronic kidney disease stages 4-5 treated or not by dialysis or kidney transplantation
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Cédric Villain, MD, PhD | Contact | +33 2 31 06 30 51 | villain-c@chu-caen.fr |
| Name | Affiliation | Role |
|---|---|---|
| Cédric Villain, MD, PhD | Department of Geriatrics, Caen University Hospital, Caen, France | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Caen University Hospital | Recruiting | Caen | 14033 | France |
Data would be available on reasonable request
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| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| ID | Term |
|---|---|
| D015577 | Geriatric Assessment |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D006304 | Health Status |
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| 1 week after kidney transplantation |
| Mortality | Death in the year following kidney transplantation | 1 year after kidney transplantation |
Cognitive functions assessed by MMSE score |
| 1 year after kidney transplantation |
| Evolution of executive functions while on waiting list and after kidney transplantation | Executive functions assessed by BREF test | 1 year after kidney transplantation |
| Evolution of mood while on waiting list and after kidney transplantation | Mood assessed by the mini GDS scale | 1 year after kidney transplantation |
| Evolution of frailty while on waiting list and after kidney transplantation | Frailty assessed by the Rockwood scale | 1 year after kidney transplantation |
| Evolution of functionnal status while on waiting list and after kidney transplantation | Functionnal status assessed by activities of daily living scales | 1 year after kidney transplantation |
| Evolution of functionnal status while on waiting list and after kidney transplantation | Functionnal status assessed by the walk speed in m/s | 1 year after kidney transplantation |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003710 |
| Demography |
| D011154 | Population Characteristics |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D015991 | Epidemiologic Measurements |
| D011634 | Public Health |
| D004778 | Environment and Public Health |