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In this study, stachyose was used as an intervention factor. We will evaluate changes in fecal gut microbiota and miRNA expression profiles in subjects under stachyose intervention
In the stachyose intervention group, each person in the stachyose intervention group took 5 g of stachyose daily before breakfast, and the administration method was 100 ml of drinking water dissolved and taken orally for two months. Each person in the placebo control group took the same amount of maltodextrin daily. Stool samples of the subjects were collected weekly.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal Control group | Placebo Comparator | Subjects with maltodextrin as intervention，5g/kg·bw/day. |
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| Stachyose intervention group | Experimental | Subjects with stachyose as intervention，5g/kg·bw/day. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| stachyose | Dietary Supplement | Stachyose is a tetrasaccharide consisting of sucrose having an alpha-D-galactosyl-(1->6)-alpha-D-galactosyl moiety attached at the 6-position of the glucose. |
| Measure | Description | Time Frame |
|---|---|---|
| expression of microRNA | small rna sequencing valuated the microRNA expression in human | up to 4 weeks |
| structure of gut microbiota | 16S rDNA sequencing valuated the gut microbiota composition in human | up to 4 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Chao Guo | Contact | 029-84775475 | 8203 | xysn@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Chao Guo | Xijing Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| the First Affiliate Hospital of the Air Force Medical University | Recruiting | Xi'an | Shaanxi | 710062 | China |
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| ID | Term |
|---|---|
| C005695 | stachyose |
| C008315 | maltodextrin |
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| Maltodextrin | Dietary Supplement | Maltodextrin is a polysaccharide that is used primarily in foods and beverages as a thickener, sweetener, and/or stabilizer. It is a relatively short-chain polymer (some would call it an oligomer); commercial products contain an average of ≈3 to ≈17 glucose units per chain. It is manufactured by partially hydrolyzing grain starches, usually corn or wheat. |
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