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| ID | Type | Description | Link |
|---|---|---|---|
| 2022-A01098-35 | Registry Identifier | ID RCB-ANSM | |
| 22-87 | Registry Identifier | CPP SUD-MED IV |
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| Name | Class |
|---|---|
| INSERM UMR-1253, Tours, France | UNKNOWN |
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An MRI Study in Subjects with Autism Spectrum Disorder and Subjects with Food Addictive Disorder compared to healthy volunteers.
An MRI Study in Subjects with Autism Spectrum Disorder and Subjects with Food Addictive Disorder compared to healthy volunteers, where pathophysiology common to both disorders, based on a dysfunction of the reward system. The project we propose aims to explore the neural networks underlying these alterations in patients suffering from autism or addictive disorder.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Autism Spectrum Disorder | Experimental | Characterized by two main diagnostic criteria: a socio-emotional deficit via a defect in communication and social reciprocity, and a behavioral deficit which manifests itself in repetitive behavioral patterns (stereotypes), restricted interests and/or activities. |
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| Food Addictive Disorders | Active Comparator | Characterized by regroup substance use disorders and behavioral addictions, are characterized in particular by the repeated occurrence of compulsive behavior and impaired social functioning |
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| Healthy volonteers | Placebo Comparator | Adult without neurological and psychiatric history, absence of progressive somatic pathologies or with vital risk. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MRI | Diagnostic Test | an fMRI measurement of the BOLD physiological signal for sensory responses |
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| Measure | Description | Time Frame |
|---|---|---|
| Blood Oxygene Level Dependent (BOLD) MRI signal | Measurement in fMRI of the BOLD signal for each condition (interest, addiction, social) will be carried out in order to highlight the possible alterations of the reward system, in particular at the level of the striatum in terms of cerebral activation for each of the groups of subjects. (FAD, ASD and HV). | At inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| Tolerance to an MRI examination for FAD with overweight or obesity | For the tolerance to an MRI examination for FAD with overweight or obesity: feedback on their experience in MRI. | At inclusion |
| Regulation of sensory, an fMRI measurement of the BOLD physiological signal for sensory responses (sensory block) in terms of brain activation in patients |
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Inclusion Criteria:
Arm A ˗ Concerning ASD patients: Adult carrying the diagnosis of ASD (DSM-5, ADOS, ADI-R criteria)
Arm B ˗ Concerning FAD patients: Adult diagnosed with FA presenting with food addiction (DSM-5, YFAS 2.0, BES >= 18 criteria).
Arm C ˗ Concerning healthy volunteers : Adult with no neurological and psychiatric history , absence of progressive somatic pathologies or with vital risk.
For all participants:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Frédéric BRIEND, PhD | Contact | +33247478519 | frederic.briend@univ-tours.fr | |
| Coralie TAILLEBUIS, MSc | Contact | +33247473909 | c.taillebuis@chu-tours.fr |
| Name | Affiliation | Role |
|---|---|---|
| Frédéric BRIEND, PhD | University Hospital,Tours -INSERM U1253 iBrain | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center-Val de Loire Region Autism Resource Center | Recruiting | Tours | 37044 | France |
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| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| D001321 | Autistic Disorder |
| ID | Term |
|---|---|
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D004569 | Electroencephalography |
| ID | Term |
|---|---|
| D003943 | Diagnostic Techniques, Neurological |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D004568 | Electrodiagnosis |
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Pilot study, monocentric open in three parallel groups (ASD, AD and healthy volunteers).
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| EEG | Diagnostic Test | These tests, through videos with a social or non-social content (human presence or absence on the stereoscopic projection), will allow us to study two types of sensorialities (visual and interoceptive). Thus, it will be possible to obtain inter- and exteroceptive profiles of the participants, a direct reflection of the processing of the internal bodily sensations of the body. |
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Regulation of sensory, an fMRI measurement of the BOLD physiological signal for sensory responses (sensory block) in terms of brain activation in patients with FAD compared to ASD subjects and healthy volunteers. |
| At inclusion |
| University Addictology Service, Liaison Team and Addictology Care | Recruiting | Tours | 37044 | France |
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| University Hospital, Medical Imaging Service | Recruiting | Tours | 37044 | France |
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