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To define the effect of crystal light, potassium citrate, or both on urinary stone risk factors in patients with a history of stone and hypocitraturia/low pH
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Potassium citrate | Active Comparator |
| |
| Crystal light | Active Comparator |
| |
| Crystal light + potassium citrate | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Potassium citrate | Drug | 7 days potassium citrate followed by 24 hour urine collection |
| |
| Measure | Description | Time Frame |
|---|---|---|
| urine citrate levels | 24 hour urine collection | Day 7 of week 1 |
| urine citrate levels | 24 hour urine collection | Day 7 of week 3 |
| urine citrate levels | 24 hour urine collection | Day 7 of week 5 |
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Inclusion Criteria:
Men and women between age 18-80 years
Willing to follow experimental protocol
Willing to complete 24-hour urine collections (three total)
Willing to sign the informed consent form
Completed Litholink Collection with blood work with results
a. hypocitraturia OR aciduria i. Hypocitraturics must meet definition of < 450 mg/day for men < 550 mg/day for women.
b. Low urine pH must be less than 5.6 c. potassium, BUN, creatinine, eGFR and hemoglobin A1c within normal limits
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Northwestern University | Chicago | Illinois | 60611 | United States |
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| ID | Term |
|---|---|
| D007669 | Kidney Calculi |
| ID | Term |
|---|---|
| D053040 | Nephrolithiasis |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| ID | Term |
|---|---|
| D019357 | Potassium Citrate |
| ID | Term |
|---|---|
| D019343 | Citric Acid |
| D002951 | Citrates |
| D014233 | Tricarboxylic Acids |
| D000144 | Acids, Acyclic |
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| Crystal light |
| Drug |
7 days crystal light followed by 24 hour urine collection |
|
| Potassium citrate + crystal light | Drug | 7 days potassium citrate + crystal light followed by 24 hour urine collection |
|
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052878 | Urolithiasis |
| D014545 | Urinary Calculi |
| D052801 | Male Urogenital Diseases |
| D002137 | Calculi |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D002264 |
| Carboxylic Acids |
| D009930 | Organic Chemicals |