Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Mahidol Oxford Tropical Medicine Research Unit | OTHER |
| Chiang Rai Clinical Research Unit, Thailand | UNKNOWN |
| Myanmar Oxford Clinical Research Unit | OTHER |
Not provided
Not provided
Not provided
Not provided
A cross-sectional household survey with two-stage cluster-randomized sampling. This cross-sectional household survey design to recruit a random sample of households that is representative for each of the study sites. From the selected households, all consenting, household members will be included in the study.
This study is funded by the UK Wellcome Trust. The grant reference number is 215604/Z/19/Z
371 households will be randomly selected from each site in Bangladesh, Cambodia, Myanmar, and Thailand. Assuming each household has an average of 4.5 members and all members will be sampled, 1500 participants will be recruited per site. This sample size allows for the overall prevalence estimation of key survey indicators with 95% confidence and 5% degree of precision.
The survey components include questionnaire interview, physical examination, blood sample collection, and point of care (PoC) tests. The questionnaire interview will collect information on household characteristics, members' disability, presence or history of disease, risk factors, self-perceived quality of life, and health seeking behaviour. For women, questions about reproductive health and antenatal care, and for young children, vaccination coverage and achievement of child development goals, will also be assessed.
For physical examinations, tympanic temperature, weight and height will be measured in all household members, mid-upper arm circumference in young children, and blood pressure in adults. Blood sample will be collected from all participants aged 6 months and above. Venous blood samples will be collected from participants aged 5 years and older, and dried blood spot will be collected from children under 5 years. Samples will be shipped to a central laboratory and analysed. Haemoglobin PoC will be administered to all participants.
All data will be collected directly on an electronic case report form using tablets, and uploaded to an electronic database.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| members of selected households at the time of survey | 371 households will be randomly selected from each site in Bangladesh, Cambodia, Myanmar, and Thailand. Assuming each household has an average of 4.5 members and all members will be sampled, 1500 participants will be recruited per site. |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of long-lasting antibodies (IgG) against selected causes of non-malaria febrile illnesses | Upon enrollment | |
| Prevalence of Plasmodium spp. by PCR | Upon enrollment | |
| Prevalence of chronic Hepatitis B and C | Upon enrollment | |
| Prevalence of selected non-communicable diseases (e.g. diabetes, chronic obstructive pulmonary diseases, stroke) according to self-reported disease history and laboratory tests | Upon enrollment | |
| Prevalence of reported disability | Upon enrollment | |
| Lifetime prevalence of reported injury or death caused by an accident | Upon enrollment | |
| Self-rated overall health status | Upon enrollment | |
| Questionnaire evaluation of health-related quality of life | Upon enrollment | |
| Prevalence of self-reported tobacco, alcohol, and other substitute use among the population aged 15 and above | Upon enrollment | |
| Prevalence of underweight and overweight, raised blood pressure and total cholesterol | Upon enrollment |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of household wealth quartile according to self-reported household characteristics | Upon enrollment | |
| Education level, marital status, and occupation | Upon enrollment | |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Households located in the survey villages and identified in the household list are eligible for the survey. All members of the randomly selected households will be recruited
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Yoel Lubell, Professor | Mahidol Oxford Tropical Medicine Research Unit | Principal Investigator |
| Thomas Peto, PhD | Mahidol Oxford Tropical Medicine Research Unit | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| BangladeshBuilding Resources Across Communities (BRAC) | Dhaka | 1212 | Bangladesh | |||
| Medical Action Myanmar (MAM) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34017924 | Background | Chandna A, Chew R, Shwe Nwe Htun N, Peto TJ, Zhang M, Liverani M, Brummaier T, Phommasone K, Perrone C, Pyae Phyo A, Sattabongkot J, Roobsoong W, Nguitragool W, Sen A, Ibna Zaman S, Sandar Zaw A, Batty E, Waithira N, Abdad MY, Blacksell SD, Bodhidatta L, Callery JJ, Fagnark W, Huangsuranun W, Islam S, Lertcharoenchoke S, Lohavittayavikant S, Mukaka M, Moul V, Kumer Neogi A, Nedsuwan S, Pongvongsa T, Ponsap P, Richard-Greenblatt M, Schilling WHK, Thaipadungpanit J, Tripura R, Dondorp AM, Mayxay M, White NJ, Nosten F, Smithuis F, Ashley EA, Maude RJ, Day NPJ, Lubell Y. Defining the burden of febrile illness in rural South and Southeast Asia: an open letter to announce the launch of the Rural Febrile Illness project. Wellcome Open Res. 2022 Mar 10;6:64. doi: 10.12688/wellcomeopenres.16393.2. eCollection 2021. | |
| 38521526 |
| Label | URL |
|---|---|
| Related Info | View source |
Not provided
With participant's consent, clinical data and results from blood analyses stored in the database may be shared according to the terms defined in the MORU data sharing policy with other researchers to use in the future.
Not provided
After completion of survey activities and reporting
MORU Data Sharing Policy
Not provided
| ID | Term |
|---|---|
| D000073296 | Noncommunicable Diseases |
| D007239 | Infections |
| ID | Term |
|---|---|
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided
| Bangladesh Rural Advancement Committee |
| OTHER |
| Cambodia Action for Health Development (AHEAD) | UNKNOWN |
Not provided
Not provided
Not provided
Venous blood samples and Dried blood spot
| Self-reported health-related household characteristics (e.g. household cooking fuel, source of drinking water, possession of mosquito net) |
| Upon enrollment |
| Proportion of population self-reported having sought for medical care in the past month, and care providers visited | Upon enrollment |
| Self-reported antenatal care coverage among women who have ever given birth | Upon enrollment |
| Reported vaccination coverage among children < 3 years | Upon enrollment |
| Prevalence of reported exclusive breast feeding among children < 5 years | Upon enrollment |
| Prevalence of children aged 3-4 years who have reached early child development milestones, reported by caretaker | Upon enrollment |
| Presence of self-reported symptoms or diagnosed illness besides the outcome measures of the primary objectives | Upon enrollment |
| Reported illness in the last month and type of illness | Upon enrollment |
| Prevalence of IgM antibodies against selected acute non-malaria causes of febrile illness | Upon enrollment |
| Yangon |
| 11201 |
| Burma |
| Cambodia Action for Health Development (AHEAD) | Battambang | Cambodia |
| Chiangrai Clinical Research Unit (CCRU) | Chiang Rai | 57000 | Thailand |
| Derived |
| Zhang M, Htun NSN, Islam S, Sen A, Islam A, Neogi AK, Tripura R, Dysoley L, Perrone C, Chew R, Batty EM, Thongpiam W, Wongsantichon J, Menggred C, Zaman SI, Waithira N, Blacksell S, Liverani M, Lee S, Maude RJ, Day NPJ, Lubell Y, Peto TJ. Defining the hidden burden of disease in rural communities in Bangladesh, Cambodia and Thailand: a cross-sectional household health survey protocol. BMJ Open. 2024 Mar 23;14(3):e081079. doi: 10.1136/bmjopen-2023-081079. |