Injectable Platelet Rich Fibrin With Collagen Matrix in Treatment of Multiple Gingival Recession.

The Value of Injectable Platelet Rich Fibrin With Volume Stable Collagen Matrix in Treatment of Multiple Gingival Recession; a Randomized Clinical Trial.

This study is proposing the use of i-PRF clot as a scaffold for the XCM in order to obtain a novel biomaterial, incorporating active growth factors and collagen matrix in a single framework, based on the potential effect of i-PRF to enhance fibroblast activity and angiogenesis stimulation for treatment of multiple gingival recession.

Inclusion Criteria:

• Presence of at least two localized gingival recessions on either sides of the maxilla and/or mandible excluding molar region.
• The cemento-enamel junction (CEJ) is visible in the teeth for root coverage procedures.
• All recessions are type 1recession RT1 (cairo et al,2011) which correspond to Miller I&II gingival recession
• All patients must demonstrate adequate plaque control with a fullmouth plaque score less than 20% and with .
• All patients at least 18 years of age and of both genders.

Exclusion Criteria:

• Smoker Patients .
• Patients with diabetes.
• Patients with a history of malignancy, radiotherapy, or chemotherapy for malignancy.
• pregnant or nursing women.
• Patients taking medications or having treatments with an effect on mucosal healing in general (e.g. steroids, large doses of antiinflammatory drugs).
• Patients with a disease affecting connective tissue metabolism.
• Patients allergic to collagen.