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This study is proposing the use of i-PRF clot as a scaffold for the XCM in order to obtain a novel biomaterial, incorporating active growth factors and collagen matrix in a single framework, based on the potential effect of i-PRF to enhance fibroblast activity and angiogenesis stimulation for treatment of multiple gingival recession.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control arm | Other | Patients with Gingival recessions are type 1 recession RT1 (cairo et al,2011) which correspond to Miller I&II gingival recession. |
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| Experimental arm | Other | Patients with Gingival recessions are type 1 recession RT1 (cairo et al,2011) which correspond to Miller I&II gingival recession. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| CAF+CM | Procedure | Periodontal surgery including CAF+CM application |
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| Measure | Description | Time Frame |
|---|---|---|
| Reduction in gingival recession depth on the buccal sides of type one gingival recessionRT1 | The primary outcome of the study is the reduction in gingival recession depth on the buccal sides of RT1 gingival recession, between the baseline preoperative measurement and follow-up at 3 months and 6 months. The Recession Depth (RD) is Measured in millimeter (mm) from CEJ (Cemento-Enamel-Junction) to the gingival margin using UNC-15 probe. | Between the baseline preoperative measurement and follow-up at 3 months and 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Improvement in Gingival Thickness (GT) | Gingival Thickness (GT) is determined at 1.5 mm apical to the gingival margin using a caliper (endodontic reamer#20) rounded to the nearest 0.1mm. | Between the baseline preoperative measurement and follow-up at 3 months and 6 months |
| Improvement in the Keratinized Tissue Height (KTH) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Basima Gh Ali, MSc | University of Baghdad | Principal Investigator |
| Thair AL Hassan, PHD | University of Baghdad | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Baghdad / College of Dentistry | Baghdad | 10047 | Iraq |
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| ID | Term |
|---|---|
| D005882 | Gingival Diseases |
| D014947 | Wounds and Injuries |
| D005889 | Gingival Recession |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D055093 | Periodontal Atrophy |
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| I-PRF | Procedure | Periodontal surgery including CAF+CM application with i-PRF |
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Keratinized Tissue Height (KTH) is measured in millimeters (mm) taken at the mid buccal aspect of the involved teeth from the gingival margin to the muco-gingival junction, by a manual periodontal probe (UNC-15 probe,Hu-Friedy,Chicago,USA). |
| Between the baseline preoperative measurement and follow-up at 3 months and 6 months |
| Reduction in the Recession Width (RW) | Recession Width (RW) is measured in millimeter (mm) at the Cement-Enamel Junction (CEJ) using UNC-15 probe. | Between the baseline preoperative measurement and follow-up at 3 months and 6 months |
| Reduction in Probing Pocket Depth (PPD) | Probing Pocket Depth (PPD) is measured in millimeter (mm) from the gingival margin to the apical extend of the probe. | Between the baseline preoperative measurement and follow-up at 3 months and 6 months |
| Reduction Clinical Attachment Level (CAL) | Clinical Attachment Level (CAL) is measured in millimeter (mm) from the CEJ to the apical extend of the probe. | Between the baseline preoperative measurement and follow-up at 3 months and 6 months |
| Measuring Plaque-Index (PI) | Plaque-Index (PI) is measured as a percentage of the presence of Plaque on four surfaces of the teeth using a manual periodontal probe. | Between the baseline preoperative measurement and follow-up at 3 months and 6 months |
| Measuring Bleeding On Probing (BOP) | Bleeding On Probing (BOP) is measured as a percentage of sites with bleeding on probing using a manual periodontal probe. | Between the baseline preoperative measurement and follow-up at 3 months and 6 months |