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| Name | Class |
|---|---|
| Tianjin Central Hospital of Gynecology Obstetrics | OTHER |
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Cefuroxime is a time-dependent antibiotic that is used to treat bacterial infections. However, population pharmacokinetic，effectiveness and safety data for cefuroxime in neonates are lacking. The aim of this study was to assess the population pharmacokinetics, effectiveness, and safety of cefuroxime in neonates.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cefuroxime | Drug | Population pharmacokinetics, effectiveness, and safety of cefuroxime |
| Measure | Description | Time Frame |
|---|---|---|
| The peak plasma drug concentration of cefuroxime | To detect the peak plasma drug concentration of cefuroxime after intravenous administration. | at (5-10) minutes after intravenous administration |
| The random plasma drug concentration of cefuroxime | To detect the random plasma drug concentration of cefuroxime after intravenous administration. | at (0.25-10) hours after intravenous administration. |
| The trough plasma drug concentration of cefuroxime | To detect the trough plasma drug concentration of cefuroxime after intravenous administration. | at 1-2 hours before the next administration |
| The time of free drug concentration exceeding the minimal inhibitory concentration (fT>MIC) | PD target | Through study completion, an average of 3 days |
| Adverse events | Drug-related adverse events and serious adverse events | Through study completion, an average of 15 days |
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Inclusion Criteria:
Exclusion Criteria:
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neonatal patients with infections
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wei Zhao, Ph.D | Contact | 86053188383308 | zhao4wei2@hotmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tianjin Central Hospital of Gynecology Obstetrics | Recruiting | Tianjin | Tianjin Municipality | 30000 | China |
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| ID | Term |
|---|---|
| D003141 | Communicable Diseases |
| ID | Term |
|---|---|
| D007239 | Infections |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D002444 | Cefuroxime |
| ID | Term |
|---|---|
| D002511 | Cephalosporins |
| D047090 | beta-Lactams |
| D007769 | Lactams |
| D000577 | Amides |
| D009930 |
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| Organic Chemicals |
| D013843 | Thiazines |
| D013457 | Sulfur Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |