Population Pharmacokinetics, Effectiveness and Safety of Cefuroxime in Neonates

Population Pharmacokinetics, Effectiveness and Safety of Cefuroxime in Neonates

Cefuroxime is a time-dependent antibiotic that is used to treat bacterial infections. However, population pharmacokinetic，effectiveness and safety data for cefuroxime in neonates are lacking. The aim of this study was to assess the population pharmacokinetics, effectiveness, and safety of cefuroxime in neonates.

Inclusion Criteria:

• Age: postnatal age ≤28 days;
• Cefuroxime used as part of antimicrobial treatment;
• Parental written consent.

Exclusion Criteria:

• Expected survival time less than the treatment cycle;
• Receiving other systemic trial drug therapy;
• Other factors that the researcher considers unsuitable for inclusion.