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This is a prospective, single-center, observational study to explore effects of bariatric surgery on different compositions of trunk fat and mechanisms.
This is a prospective, single-center, observational study to explore effects of bariatric surgery on different compositions of trunk fat and mechanisms. The primary outcome is effects of bariatric surgery on different compositions of trunk fat evaluated with MRI for patients pending bariatric surgery before and 3 months after surgery. The secondary outcome is the associations of trunk fat reduction with improvement in metabolism indicators. Before patients are enrolled in this observational study, the researchers will do a detailed screening of the subjects based on the inclusion criteria and the exclusion criteria to determine if the patients are appropriate for the study. Patients who meet the conditions of the study will be required to sign an informed consent form.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients pending bariatric surgery | A continuous cohort of patients pending bariatric surgery |
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| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline Subcutaneous Fat Area at 3 months after bariatric surgery | Change from baseline subcutaneous fat area (unite in cm3) evaluated with MRI at 3 months after bariatric surgery. | Baseline and 3 months after sugery |
| Change from Baseline Visceral Fat Area at 3 months after bariatric surgery | Change from baseline visceral fat area (unite in cm3) evaluated with MRI at 3 months after bariatric surgery. | Baseline and 3 months after sugery |
| Change from Baseline Liver Fat Percentage at 3 months after bariatric surgery | Change from baseline liver fat percentage (unite in %) evaluated with MRI at 3 months after bariatric surgery. | Baseline and 3 months after sugery |
| Change from Baseline Pancreatic Fat Percentage at 3 months after bariatric surgery | Change from baseline pancreatic fat percentage (unite in %) evaluated with MRI at 3 months after bariatric surgery. | Baseline and 3 months after sugery |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation coefficient of trunk fat change with change in metabolism indicators | Correlation coefficient of trunk fat changes with changes in metabolism indicators.
|
| Measure | Description | Time Frame |
|---|---|---|
| Age | Age of participants (unite in year) | Baseline |
| Gender | Gender of participants | Baseline |
Inclusion Criteria:
Exclusion Criteria:
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Patients pending bariatric surgery.
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| Name | Affiliation | Role |
|---|---|---|
| Shaihong Zhu, M.D. | The Third Xiangya Hospital of Central South University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Third Xiangya Hospital of Central South University | Changsha | Hunan | 410013 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37352520 | Derived | Cui B, Duan J, Zhu L, Wang G, Sun X, Su Z, Liao Y, Yi B, Li P, Li W, Song Z, Li Z, Tang H, Rong P, Zhu S. Effect of laparoscopic sleeve gastrectomy on mobilization of site-specific body adipose depots: a prospective cohort study. Int J Surg. 2023 Oct 1;109(10):3013-3020. doi: 10.1097/JS9.0000000000000573. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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Plasma for estimates of metabolism indicators
| Baseline and 3 months after sugery |
| Duration of Type 2 diabetes | Duration of Type 2 diabetes of participants (unite in year) | Baseline |
| Number of medicine use | Number of medicine use of participants | Baseline and 3 months after sugery |
| Weight | Weight of participants (unite in kg) | Baseline and 3 months after sugery |
| Body mass index | Body mass index of participants (unite in kg/m2) | Baseline and 3 months after sugery |
| Waist circumference | Waist circumference of participants (unite in cm) | Baseline and 3 months after sugery |
| Hip circumference | Hip circumference of participants (unite in cm) | Baseline and 3 months after sugery |
| Fasting plasma glucose | Fasting plasma glucose of participants (unite in mmol/L) | Baseline and 3 months after sugery |
| Glycated hemoglobin |glycosylated hemoglobin | Glycated hemoglobin |glycosylated hemoglobin of participants (unite in %) | Baseline and 3 months after sugery |
| Fasting insulin | Fasting insulin of participants (unite in uU/mL) | Baseline and 3 months after sugery |
| Fasting C-peptide | Fasting C-peptide of participants (unite in ng/mL) | Baseline and 3 months after sugery |
| Homeostatic Model Assessment of Insulin Resistance | Homeostatic Model Assessment of Insulin Resistance of participants | Baseline and 3 months after sugery |
| Low-Density Lipoprotein Cholesterol | Low-Density Lipoprotein Cholesterol of participants (unite in mmol/L) | Baseline and 3 months after sugery |
| High-Density Lipoprotein Cholesterol | High-Density Lipoprotein Cholesterol of participants (unite in mmol/L) | Baseline and 3 months after sugery |
| Cholesterol | Cholesterol of participants (unite in mmol/L) | Baseline and 3 months after sugery |
| Triglyceride | Triglyceride of participants (unite in mmol/L) | Baseline and 3 months after sugery |
| Subcutaneous Fat Area | Subcutaneous Fat Area of participants evaluated with MRI (unite in cm3) | Baseline and 3 months after sugery |
| Visceral Fat Area | Visceral Fat Area of participants evaluated with MRI (unite in cm3) | Baseline and 3 months after sugery |
| Liver Fat Percentage | Liver Fat Percentage of participants evaluated with MRI (unite in %) | Baseline and 3 months after sugery |
| Pancreatic Fat Percentage | Pancreatic Fat Percentage of participants evaluated with MRI (unite in %) | Baseline and 3 months after sugery |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |