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In our study, three different medicaments were evaluated in terms of postoperative complications after free gingival grafting (FGG).
In our study, three different medicaments were evaluated in terms of postoperative complications after free gingival grafting. The effectiveness of these 3 different commercially available agents containing flurbiprofen, hyaluronic acid, and hypochlorous acid, after use 2., 4.7. and on the 14th day, wound healing and pain perception was compared with the control group. primary observation was obtained by visual analog scale, wound healing index, bleeding of tissue, color match, and amount of painkiller used by the patient were also recorded
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Patients were not given anything after FGG. |
| |
| Flurbiprofen | Oral spray containing 0.075 g flurbiprofen administered after FGG |
| |
| Hypochlorous acid | Oral spray containing hypochlorous acid applied after FGG |
| |
| Hyaluronic acid | An oral spray containing the main component of the product is hyaluronic acid (sodium salt) with a high molecular weight of 30 mg / 100 g was given to patients after FGG |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Majezik %0.25 oral spray | Drug | Free gingival graft was taken from the palatal mucosa of the patients in order to increase the attached gingiva. After FGG, the patients were asked to apply this spray to the palatal mucosa 3 times a day. |
| Measure | Description | Time Frame |
|---|---|---|
| Landry's Wound Healing Index (WHI) | WHI was performed on the basis of postoperative healing characteristics categorized as tissue color, response to palpation, incision margins, and suppuration. | 21 days |
| Measure | Description | Time Frame |
|---|---|---|
| Visual Analogue Scale | Recording the pain perception of the patients on a scale from 0 to 10. 0 - no pain 10 - worst pain | 21 days |
| Color match | scoring the color match of the healed tissue area with the patient's remaining tissue |
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Inclusion Criteria:- Patients with systematic conditions are classified as The American Society of Anesthesiologists Class I
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Exclusion Criteria:
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The population of the study consists of all patients, who were planned to be applied free gingival graft for mucogingival surgery
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| Name | Affiliation | Role |
|---|---|---|
| AYSAN LEKTEMUR ALPAN, PhD | Pamukkale Univesity | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pamukkale University Faculty of Dentistry Department of Periodontology | Denizli | 20070 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30007054 | Background | Isler SC, Eraydin N, Akkale H, Ozdemir B. Oral flurbiprofen spray for mucosal graft harvesting at the palatal area: A randomized placebo-controlled study. J Periodontol. 2018 Oct;89(10):1174-1183. doi: 10.1002/JPER.17-0381. Epub 2018 Aug 29. | |
| 34426739 | Background | Hassan A, Ahmed E, Ghalwash D, Elarab AE. Clinical Comparison of MEBO and Hyaluronic Acid Gel in the Management of Pain after Free Gingival Graft Harvesting: A Randomized Clinical Trial. Int J Dent. 2021 Aug 14;2021:2548665. doi: 10.1155/2021/2548665. eCollection 2021. |
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We may share the obtained data personally, but the decision of this is not yet clear.
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| Aftamed oral spray | Other | Free gingival graft was taken from the palatal mucosa of the patients in order to increase the attached gingiva. After FGG, the patients were asked to apply this spray to the palatal mucosa 3 times a day. |
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| Crystalin oral spray | Other | Free gingival graft was taken from the palatal mucosa of the patients in order to increase the attached gingiva. After FGG, the patients were asked to apply this spray to the palatal mucosa 3 times a day. |
|
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| Free gingival graft harvesting | Procedure | Free gingival graft was taken from the palatal mucosa of the patients in order to increase the attached gingiva. |
|
| 21 days |
| delayed bleeding | examining the patient whether there is postoperative bleeding, if there is a positive, if not, it should be recorded as negative. | 21 days |
| burning sensation | Evaluation of the burning sensation felt in the healing area of the patient's palate from 0 to 10. 0-no burning sensation 10- excessive burning | 21 days |
| complete epithelization | Examination of epithelialization with 3% oxygenated water. keeping records according to the foaming rate in the tissue | 21 days |
| 28914592 | Background | Yildirim S, Ozener HO, Dogan B, Kuru B. Effect of topically applied hyaluronic acid on pain and palatal epithelial wound healing: An examiner-masked, randomized, controlled clinical trial. J Periodontol. 2018 Jan;89(1):36-45. doi: 10.1902/jop.2017.170105. |
| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| D006470 | Hemorrhage |
| D000377 | Agnosia |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009422 | Nervous System Diseases |
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