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The Ezra Faster Scan study uses non-invasive magnetic resonance imaging (MRI) technology that can "visually" detect early and late-stage cancer, and other pathologies. MRIs use a magnetic field and radio waves to create a 3-dimensional (3D) image of an individual's body without using ionizing radiation.
The purpose of this research is to decrease the amount of time required by an individual to complete an early cancer screening comprehensive magnetic resonance imaging (MRI) scan, such as the Ezra Full Body MRI imaging scan. If the time required to conduct a comprehensive scan is reduced, the cost of the scan may also decrease. By decreasing consumer costs and time, more individuals may be able to afford MRI-based early cancer screening technology.
Participants in this study will undergo a minimum 30-minute MRI session. These sessions will be used to evaluate new MRI "instructions" that allow for a faster MRI scan time. The images will also be used to develop mathematical models or machine learning tools that allow images to be enhanced. By enhancing images using machine learning, they may be restored to a quality typically observed in MRI sessions with longer scan (acquisition) times.
To read more about the study, potential participants may review the informed consent form located below in the References section. Potential participants may email research.fasterscan@ezra.com, or call 516.340.1221.
See study Eligibility Criteria below.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Observational | The observational group may include those 18 years and older, with retrospective MRI data, or those whom prospective MRI images are collected as a participant. This study is decentralized, non-therapeutic and non-interventional. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Magnetic Resonance Imaging | Other | Participants are required to undergo a non-invasive magnetic resonance imaging (MRI) scan approximately 30 minutes in length. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Accelerated MRI Sequence Protocol Time (s) | The MRI scan time (minutes, seconds) for MRI instructions or sequences to be completed and qualitative feedback from MRI technologists and radiologists on execution of instrument instructions. | Approximately 30 minutes for each participant scan . Additional computational analysis of images throughout the study duration. |
| Statistical Analysis of MRI Images (Accelerated) | Computed image signal-to-noise and contrast-to-noise ratios of machine learning-restored accelerated images relative to accelerated images. | Approximately 30 minutes for each participant scan. Additional computational analysis of images throughout the study duration. |
| Statistical Analysis of MRI Images (Reference) | Computed image signal-to-noise and contrast-to-noise ratios of machine learning-restored accelerated images relative to reference images. | Approximately 30 minutes for each participant scan. Additional computational analysis of images throughout the study duration. |
| Statistical Analysis of MRI Images (Likert) | Visual radiologist review of reference and machine learning restored images. Images are reviewed using a Likert scale, comparing a reference image to a machine learning restored image. The scale grades are a radiologist's objective opinion of whether a machine learning restored image is similar to a reference image. If the machine learning image is worse, the radiologist rates the image strongly disagree or -2, if the machine learning image is better than the reference image, the radiologist selects strongly agree or 2. The Likert scale extends from worse to improved in the following order; strongly disagree (worse) -2, disagree -1, neither agree or disagree (neutral) 0, agree 1, or strongly agree 2. The minimum value is -2 and the maximum value is 2. A higher score greater than 0 indicates a better image, a lower score less than 0 indicates a worse image or outcome. | Approximately 10 minutes of a radiologist's time. Additional analysis of images throughout the study duration. |
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Inclusion Criteria:
Exclusion Criteria:
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Participants may be from the general public and located or able to travel to MRI facilities located in New York, New York; Queens, New York; Brooklyn, New York; Great Neck, New York; Irvine, California; Sunnyvale, California; Walnut Creek, California; San Francisco, California; Miami, Florida; Aventura, Florida. Participants may also be those who have accessed Ezra commercial MRI services in the past, or have scheduled commercial MRI services pending.
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| Name | Affiliation | Role |
|---|---|---|
| David Girard | Ezra AI, Inc. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Various Locations | Beverly Hills | California | 90211 | United States | ||
| Various Locations |
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| ID | Type | URL | Comment |
|---|---|---|---|
| Informed Consent Form | View IPD |
Deidentified data may be shared for the purpose of research. Algorithms based on research may be commercialized or published.
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D009682 | Magnetic Resonance Spectroscopy |
| ID | Term |
|---|---|
| D013057 | Spectrum Analysis |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |
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|
| Chino Hills |
| California |
| 91709 |
| United States |
| Various Locations | Irvine | California | 92604 | United States |
| Various Locations | Los Gatos | California | 95032 | United States |
| Various Locations | New York | New York | 10075 | United States |
This link will download the informed consent document for the Faster Scan Study. In this document potential participants will find additional information about the study. |