Endodontic Microsurgery With the Use of L-PRF Block

Endodontic Microsurgery With the Use of L-PRF Block: a Randomized Controlled Clinical Trial

This study evaluates the effect of leucocyte and platelet rich fibrin Block (L-PRF Block) during endodontic microsurgery (EMS) on patient's post-operative comfort and periapical bone healing in large peri-apical lesions.

This study evaluates the effect of leucocyte and platelet rich fibrin Block (L-PRF Block) during endodontic microsurgery (EMS) on patient's post-operative comfort and periapical bone healing in large peri-apical lesions. The trial design is an open randomized controlled clinical trial with two groups. Half of the participants will receive EMS with L-PRF Block (experimental group), the other half without (control group).

Inclusion Criteria

• Provision of Informed Consent
• Patients from 18 years old
• Patients in need of an EMS
• EMS is the only option to cure the periapical lesion
• A periapical lesion that has a diameter of 10mm or more in sagittal plane, frontal plane or axial plane when measured on CBCT

Exclusion Criteria

• Unlikely to be able to comply with the study procedures, as judged by the investigator
• Orthograde endodontic (re)treatment is indicated
• Known or suspected current malignancy
• History of chemotherapy within 5 years prior to study
• History of radiation in the head and neck region
• History of other metabolic bone diseases
• History of bleeding disorders
• HIV disease
• Hepatitis B or C
• Systemic disease (osteoporosis, diabetes…)