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| Name | Class |
|---|---|
| University of Aarhus | OTHER |
| Odense University Hospital | OTHER |
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This pilot study aims at describing the prevalence and distribution of molecular alterations in thyroid nodules of benign and malignant origin at the level of DNA and RNA in a Danish population.
Patients with thyroid nodules suspected of malignancy is included prospectively.
Tissue samples are collected for molecular analyses form surgical specimens and bloodsamples, and preoperative clincial features are registered.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Molecular testing | Experimental | Descriptive and explorative study including identical molecular analyses applied to all included patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Molecular analyses | Genetic | Collect thyroid tissue for molecular analysis from the histological specimen collected by routine surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| DNA alterations | Whole genome sequencing by next generation sequencing | Two years |
| RNA alterations | Total RNA sequencing including circular RNA, micro RNA and messenger RNA | Two years |
| DNA methylation | Whole Genome Bisulfite Sequencing | Two years |
| Circulating tumor DNA | Whole genome sequencing of leucocyt DNA and circularing DNA | Two years |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kristine Z Swan | Aarhus University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aarhus Universityhospital | Aarhus N | 8200 | Denmark |
IPD will be in accordance with Danish legislation and regulations within the area
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| ID | Term |
|---|---|
| D016606 | Thyroid Nodule |
| D004194 | Disease |
| D013964 | Thyroid Neoplasms |
| ID | Term |
|---|---|
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D006258 | Head and Neck Neoplasms |
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| ID | Term |
|---|---|
| D062105 | Molecular Docking Simulation |
| ID | Term |
|---|---|
| D008958 | Models, Molecular |
| D008962 | Models, Theoretical |
| D008919 | Investigative Techniques |
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| D004700 |
| Endocrine System Diseases |
| D013959 | Thyroid Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |