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The inclusion objective was not achieved. Given the exploratory nature of the study, we have decided not to extend the study
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Primary Ciliary Dyskinesia associated with abnormalities of lateralization of organs (with existence of a situs inversus in 50% of cases) and secondary fertility disorders related in humans to abnormalities of mobility of sperm but very little data on the structure and function of tubal cilia in women
Primary Ciliary Dyskinesia (DCP) is a rare genetic disease (1 in 15,000 individuals at birth), which manifests itself in chronic respiratory infections (bronchopneumopathies and rhinosinusitis type) associated with abnormalities of lateralization of organs (with existence of a situs inversus in 50% of cases) and secondary fertility disorders related in humans to abnormalities of sperm mobility. However, there is very little data in the literature on the structure and function of tubal cilia in women with DCP.
Before considering a study of tubal cilia in patients with DCP, it seems necessary to specify in DCP patients or not DCP, the molecular and morphological composition of tubal cilia and to look for ciliary abnormalities in case of GEU
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Salpingectomy for Extra-Uterine Pregnancy | Experimental | patients with salpingectomy for Ectopic Pregnancy |
|
| hysterectomies | Sham Comparator | patients with hysterectomy for prolapsus, adenomyosis or myomectomy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| salpingectomy | Procedure | Removal of one of the fallopian tubes. |
|
| Measure | Description | Time Frame |
|---|---|---|
| morphological of tubal cilia | Molecular compositor of tubal ciliar by immunofluorescence study of 14 proteins in vivo and in vitro (tissue cells from patient fallopian tubes) | through study completion, an average of 6 week after surgery |
| Molecular difference in tubal cilia between patients with or without GEU salpingectomy | compares molecular compositor of tubal ciliar by immunofluorecence study of 14 proteins in vivo and in vitro between patients with or without GEU salpingectomy | through study completion, an average of 6 week after surgery |
| molecular tubal cilia | Ultrastructure morphology of tubal cell cilia by electron microscopy | through study completion, an average of 6 week after surgery |
| functional composition of tubal cell by video microscopy | amplitude of moment by video microscopy | through study completion, an average of 6 week after surgery |
| functional composition of tubal cell by video microscopy | frequency of moment by video microscopy | through study completion, an average of 6 week after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Rana i MITRI-FRANGIEH | Centre Hospitalier Intercommunal Créteil | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Intercommunal Créteil | Créteil | Val-deMarne | 94000 | France |
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| ID | Term |
|---|---|
| D002925 | Ciliary Motility Disorders |
| D011271 | Pregnancy, Ectopic |
| D000022 | Abortion, Spontaneous |
| ID | Term |
|---|---|
| D012140 | Respiratory Tract Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D000072661 | Ciliopathies |
| D000015 | Abnormalities, Multiple |
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| ID | Term |
|---|---|
| D058994 | Salpingectomy |
| D007044 | Hysterectomy |
| ID | Term |
|---|---|
| D013509 | Gynecologic Surgical Procedures |
| D013519 | Urogenital Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
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| hysterectomy | Procedure | remove the uterus, whole or only part. It may also involve the removal of the cervix, ovaries, fallopian tubes and other surrounding structures. |
|
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D030342 | Genetic Diseases, Inborn |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |