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Background : The supplementary motor area is the most common/preferential brain location of LGG. This area plays an important role in many motor and cognitive functions such as motor initiation, bimanual coordination and executive functions. Many studies describe the supplementary motor area syndrome resulting from lesions in this area. News managements for LGGs consisting in intraoperative mapping in awake patients reduce significantly neurological disorders and increase also the overall survival . However, the literature does not provide data concerning motor and cognitive functions in a long term and their consequences in the quality of life of patients.
Objective : The aim of our research project is to identify whether there are some motor or neurocognitive deficit in the short and the long term in a population of patients who have medical story of LGG resection in the supplementary motor area.
Patients and Methods : 20 patients who have medical story of LGG in the supplementary motor area and 20 patients who have medical story of LGG resection in other locations are recruited. Firstly, patients have to complete a self-assessment questionnaire about their quality of life, sent by regular mail or e-mail. Then, patients are admitted on the same day as their follow up visit and underwent motor and neurocognitive screening tests ( "Bilan des 400 points", Tests of Attentional Performances) for an hour. The investigators will analyse data and compare between the 2 groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Case | patients with a history of surgical removal of diffuse low grade glioma located in the supplementary motor area |
| |
| Control | patients with a history of surgical removal of diffuse low-grade glioma located in another brain area |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Test battery | Other | motor and neuropsychological test battery |
|
| Measure | Description | Time Frame |
|---|---|---|
| motor tests in the case group - 400 point assessment | analysis of the scores obtained at the tests 4 tests :
| inclusion visit |
| neuropsychological tests in the case group | analysis of the scores obtained Phase alert system
Flexibility
Incompatibility
RT min : 0 SD min : 0 No maximum value: calculation against standard values | inclusion visit |
| Measure | Description | Time Frame |
|---|---|---|
| motor tests in the control group - 400 point assessment | analysis of the scores obtained at the tests 4 tests :
| inclusion visit |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients with low-grade diffuse glioma resection visiting the university hospital for a follow-up neurosurgical consultation
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| Name | Affiliation | Role |
|---|---|---|
| Ilyess ZEMMOURA | University Hospital, Tours | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University hospital | Tours | 37044 | France |
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| neuropsychological tests in the control group | analysis of the scores obtained Phase alert system
Flexibility
Incompatibility
RT min : 0 SD min : 0 No maximum value: calculation against standard values | inclusion visit |
| Brain MRI | Analysis of the location of diffuse low-grade gliomas | inclusion visit |
| Brain MRI | Analysis of the lesion volume of diffuse low-grade gliomas | inclusion visit |
| quality of life self-questionnaire carried out at home : sickness Impact Profile | analysis of the results obtained 136 questions with responses True or False Minimum value = 0 Maximum value = 136 136/136 means that the quality of life is very negatively affected | inclusion visit |
| fatigue self-questionnaire carried out at home : fatigue Impact Scale (FIS) | analysis of the results obtained 40 questions with responses
| inclusion visit |
| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| D000068079 | Motor Disorders |
| D005910 | Glioma |
| D009422 | Nervous System Diseases |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D018302 | Neoplasms, Neuroepithelial |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009380 | Neoplasms, Nerve Tissue |
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