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Infertility is a disease that seriously affects the physical and mental health of women of childbearing age. The incidence of infertility has been increasing in recent years. Studies have shown that the occurrence of infertility may be related to environmental endocrine disrupting substances. This project was designed to establish a cohort study on environmental endocrine disrupting substances and in vitro fertilization (IVF) treatment, collect blood, urine, semen, follicular fluid, granulosa cells, chorionic decidua biological specimens, and then follow up on the pregnancy outcomes. The concentration of disrupting substances was detected and then found the associations between environmental endocrine disrupting substances and female reproductive health.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| there is no intervention in the study | Other | there is no intervention in the study |
| Measure | Description | Time Frame |
|---|---|---|
| Number of eggs retrieved | the number of eggs retrieved in the process of in vitro fertilization (IVF) | immediately after the eggs retrieved |
| the number of available embryos | the number of available embryos in the process of IVF | 1 week after the eggs retrieved |
| the clinical pregnancy rate | the clinical pregnancy rate in the process of IVF | 4 weeks after the embryos transfer |
| the miscarriage rate | the miscarriage rate in the process of IVF | 7 months after embryos transfer |
| the live birth rate | the live birth rate in the process of IVF | 40 weeks after embryos transfer |
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Inclusion Criteria:
Clinical diagnosis of infertile patients undergoing IVF treatment
Exclusion Criteria:
Donor egg transplants excluded
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All the couples intended to receive the treatment of IVF can be included in the study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Huan Shen, Doctor | Contact | 86010-88324436 | rmivf@sina.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking University People's Hospital | Recruiting | Beijing | Beijing Municipality | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39892082 | Derived | Wang H, Liang Y, Dong X, Fu M, Wang Y, Wang Y, Han H, Wang M, Zuo Y, Zhang S, Shen H, Han F, Gao F. Association between snoring and in vitro fertilization outcomes among infertile women. Sleep Med. 2025 Apr;128:74-81. doi: 10.1016/j.sleep.2025.01.013. Epub 2025 Jan 21. |
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the urine, blood, follicular fluid，semen，villous tissue and placenta