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in this study, the investigators aim to describe the effects of highflow nasal canulae oxygen therapy (HFNC) on respiratory muscle function during exercise in patients with fibrosing interstitial lung diseases (ILD) during an endurance test
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Venturi mask | Experimental | Patients will be placed under oxygen therapy with Venturi mask at a constant flow of 15L/min and a set FiO2 of 50%. The real FiO2 will be mesured in the mask at rest. |
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| High flow nasal canulae | Experimental | Patients will be placed under high flow nasal canulae oxygen therapy with a constant flow of 50L/min and the real FiO2 provided by Venturi mask. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| high flow nasal canulae | Device | high flow nasal canulae is a oxygen therapy technic which allows the administration of warmed and humidified oxygen with a flow up to 50L/Min and a monitored FiO2. Physiological previous studies reported various effects of this technic especially on work of breathing. In our study the investigators aim to test this physiological property during exercise. |
| Measure | Description | Time Frame |
|---|---|---|
| Ptdi swing | To compare the change in transdiaphragmatic pressure between baseline and peak during inspiration (Ptdi swing) between HFNC and VM in patients with fibrosing Interstitial Lung Disease in stable state, at isotime. | during the intervention, at isotime |
| Measure | Description | Time Frame |
|---|---|---|
| PTPdi | on effort at isotime, comparison between HFNC and VM of diaphragmatic pressure time product during a respiratory cycle (PTPdi) | during the intervention, at isotime |
| PTPoeso | on effort at isotime, comparison between HFNC and VM of the respiratory "Pressure Time Product" during a respiratory cycle (PTPoeso) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Elise ARTAUD-MACARI, MD | Contact | +3332 88 59 92 | eliseartaudmacari@yahoo.fr | |
| Maryline LEFORT | Contact | +3332 88 59 92 | mlefort@adir-hautenormandie.com |
| Name | Affiliation | Role |
|---|---|---|
| Elise ARTAUD-MACARI, MD | ADIR Association | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| ADIR association | Recruiting | Bois-Guillaume | 76230 | France |
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| ID | Term |
|---|---|
| D017563 | Lung Diseases, Interstitial |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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All patients were randomly allocated into two groups using the block randomization technique (blocks of eight patients) in a 1:1 ratio. In group A, a high-intensity constant work-rate endurance test using Venturi mask (VM) was performed on first, and a test using high-flow nasal canulae oxygen therapy (HFNC) was performed next. In group B, a high-intensity CWRET using HFNC was performed first, and a test using VM was performed next.
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| Ventury mask | Device | Ventury mask is a oxygen therapy technic which allows the administration with a mask of oxygen with a flow up to 15L/Min and a monitored FiO2. |
|
| during the intervention, at isotime |
| Poeso swing | on effort at isotime, comparison between HFNC and VM of variation of oesophagal pressure between the base state and the peak (Poeso swing) | during the intervention, at isotime |
| DeltaPtdi/DeltaEAdi | on effort at isotime, comparison between HFNC and VM of the electromechanical coupling of the diaphragm (ratio of variation of the transdiaphragmatic pressure by the variation of electrical activity of the diaphragm (EAdi) between the start of inspiration and the end of expiration, (DeltaPtdi/DeltaEAdi) | during the intervention, at isotime |
| SmO2 | on effort at isotime, comparison between HFNC and VM of the measurement of tissue saturation in oxygen (SmO2) by "Near Infrared Spectrometry" (NIRS) | during the intervention, at isotime |
| TcCO2 | on effort at isotime, comparison between HFNC and VM of transcutaneous CO2 measurement (TcCO2) | during the intervention, at isotime |
| Tlim | Comparison of endurance time (Tlim) between HFNC and VM | during the intervention, at the end of endurance test |