Fructose Effect on Neuroinflammation and Feelings

Fructose Effect on Neuroinflammation and Feelings: Direct Action on the Brain or Indirect by the Intestinal Microbiota?

Fructose is increasingly present in our food. The increase in its consumption is associated with the increase in the prevalence of several pathologies such as metabolic syndrome or hepatic steatosis. The effect of fructose consumption on brain health has been poorly studied. Studies in animal models show that diets enriched in fructose promote the development of emotional behavior disorders. Fructose malabsorption is also associated with changes in the microbiota that could also impact brain health. However, no human study to date has associated fructose malabsorption with changes in the gut microbiota and effects on brain health.

The objective of this study is to study the emotional behavior of a population of healthy volunteers according to the presence or not of fructose malabsorption. Patients with fructose malabsorption are susceptible to gut dysbiosis without necessarily consuming high amounts of fructose.

Inclusion Criteria:

• Healthy volunteers
• Aged 18 to 35
• Male sex
• BMI between 18.5 and 25
• Affiliation to a social security scheme
• Adult patient having read and understood the information letter and signed the consent form

Exclusion Criteria:

• Presence of irritable bowel syndrome, celiac disease
• Presence of a psychiatric illness
• Presence of a neurodegenerative disease
• Presence of an eating disorder
• Presence of chronic disease, including inflammatory disease
• Presence of diabetes
• Presence of an acute infectious disease
• Presence of a surgical history of the digestive tract (excluding appendectomy)
• Taking long-term treatment
• Taking antibiotics within 6 months
• Taking probiotics within 3 months
• Typical diet low in lactose, FODMAP, gluten, vegetarian, vegan, vegan, chromonutrition .... in progress
• Smoker
• Person deprived of liberty by an administrative or judicial decision or person placed under judicial protection / under guardianship or guardianship
• Simultaneous participation in another interventional clinical trial