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With the continuous advancement of ultrasonic technology, nerve block in which drugs are injected into the periphery of the target nerve through ultrasonic guidance has become the mainstream method for postoperative pain control. The quadratus lumborum nerve block has been effectively and safely used in abdominal surgery (such as laparotomy, caesarean section, etc.), effectively reducing postoperative wounds and visceral pain. There is no research on the use of quadratus lumborum nerve block to control the pain of natural postpartum uterine contractions in the current literature, so the purpose of this experiment is to explore whether the quadratus lumborum nerve block can effectively reduce the pain of uterine contractions after vaginal delivery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| quadratus lumborum nerve block group with injection of local anesthetic (Ropivacaine) | Experimental | The subjects would have quadratus lumborum nerve block group with injection of local anesthetic (Ropivacaine) after vaginal delivery. |
|
| quadratus lumborum nerve block with normal saline | Placebo Comparator | The subjects would have quadratus lumborum nerve block with normal saline after vaginal delivery. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| quadratus lumborum nerve block (ropivacaine ) | Procedure | Echo guided quadratus lumborum nerve block with ropivacaine |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pain associated with uterine contractions | Grading with Numerical Pain Scale [0 (no pain at all) to 10 (worst imaginable pain)] and Visual Analogue Scale [mark a position between 0 (no pain at all) to 10 (worst imaginable pain)] | Right before intervention |
| Pain associated with uterine contractions | Grading with Numerical Pain Scale [0 (no pain at all) to 10 (worst imaginable pain)] and Visual Analogue Scale [mark a position between 0 (no pain at all) to 10 (worst imaginable pain)] | 1 hour after intervention |
| Pain associated with uterine contractions | Grading with Numerical Pain Scale [0 (no pain at all) to 10 (worst imaginable pain)] and Visual Analogue Scale [mark a position between 0 (no pain at all) to 10 (worst imaginable pain)] | 6 hours after intervention |
| Pain associated with uterine contractions | Grading with Numerical Pain Scale [0 (no pain at all) to 10 (worst imaginable pain)] and Visual Analogue Scale [mark a position between 0 (no pain at all) to 10 (worst imaginable pain)] | 12 hours after intervention |
| Pain associated with uterine contractions | Grading with Numerical Pain Scale [0 (no pain at all) to 10 (worst imaginable pain)] and Visual Analogue Scale [mark a position between 0 (no pain at all) to 10 (worst imaginable pain)] | 24 hours after intervention |
| Pain associated with uterine contractions | Grading with Numerical Pain Scale [0 (no pain at all) to 10 (worst imaginable pain)] and Visual Analogue Scale [mark a position between 0 (no pain at all) to 10 (worst imaginable pain)] |
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| Measure | Description | Time Frame |
|---|---|---|
| Edinburgh Postnatal Depression Scale | Edinburgh Postnatal Depression Scale 10-item (ranging from 0 to 30, possible depression > 10) | Right before intervention |
| Pittsburgh sleep quality index | Pittsburgh sleep quality index (ranging from 0 to 21, where lower scores denote a healthier sleep quality) |
Inclusion Criteria:
Exclusion Criteria:
Female had maternal vaginal delivery
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chang Gung Memorial Hospital (Linkou) | Taoyuan City | 33305 | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42255090 | Derived | Cheng WS, Chen YT, Chao WH, Liao CC. Quadratus Lumborum Block Reduced Postpartum Uterine Pain After Normal Spontaneous Delivery: A Prospective, Randomized, Double-Blind, Controlled Trial. Health Sci Rep. 2026 May 31;9(6):e72586. doi: 10.1002/hsr2.72586. eCollection 2026 Jun. |
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| ID | Term |
|---|---|
| D000077212 | Ropivacaine |
| D000077330 | Saline Solution |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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Fifty subjects were randomly assigned to the quadratus lumborum nerve block group with injection of local anesthetic (Ropivacaine), and another 50 subjects were assigned to the quadratus lumborum nerve block with normal saline injection. The total number of subjects involved is one hundred.
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After the computer program (SASĀ® 9.4) generates the groups of subjects in random order, a third-party person who is not the research team will put the groups into envelopes numbered one to one hundred in sequence. Which group the subjects will be assigned to will not be known to members of the research team until the trial is unblinded.
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| quadratus lumborum nerve block (normal saline) | Procedure | Echo guided quadratus lumborum nerve block with normal saline |
|
|
| 36 hours after intervention |
| Pain associated with uterine contractions | Grading with Numerical Pain Scale [0 (no pain at all) to 10 (worst imaginable pain)] and Visual Analogue Scale [mark a position between 0 (no pain at all) to 10 (worst imaginable pain)] | 48 hours after intervention |
| Right before intervention |
| Modified Fatigue Symptoms Checklist | Modified Fatigue Symptoms Checklist (ranging from 0 to 40, where higher scores mean more exhausted physical and mental status) | Right before intervention |
| Postpartum Perceived Stress Scale | Postpartum Perceived Stress Scale - 14 items (range from 0 to 70 with higher scores indicating higher perceived stress) | Right before intervention |
| Edinburgh Postnatal Depression Scale | Edinburgh Postnatal Depression Scale 10-item (from 0 to 30, possible depression > 10) | 48 hours after intervention |
| Pittsburgh sleep quality index | Pittsburgh sleep quality index Modified Fatigue Symptoms Checklis (ranging from 0 to 21, where lower scores denote a healthier sleep quality) | 48 hours after intervention |
| Modified Fatigue Symptoms Checklist | Modified Fatigue Symptoms Checklist (ranging from 0 to 40, where higher scores mean more exhausted physical and mental status) | 48 hours after intervention |
| Postpartum Perceived Stress Scale | Postpartum Perceived Stress Scale - 14 items (range from 0 to 70 with higher scores indicating higher perceived stress) | 48 hours after intervention |
| D000588 |
| Amines |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |