Retrospective study at the Brest universitary hospital to evaluate the efficacy of methotrexate (MTX) and azathioprine (AZA) in background treatment of unidentified non anterior uveitis.

Uveitis is a major cause of ocular damage, responsible for 5 to 10% of blindness in the world. More broadly, up to 35% of patients with uveitis have visual acuity impairment ranging from "significant" to "legal blindness" [4]. The figures of "legal blindness" up to 25% according to the studies

The objective of any anti-inflammatory therapy strategy for uveitis is to:

• Quickly control eye inflammation to minimize irreversible structural damage and maintain visual function.
• Prevent inflammatory recurrences, which cause complications and co-morbidity.
• Limit the use of systemic corticosteroids over the course of their deleterious metabolic effects.
• Optimize the risk-benefit balance and promote compliance.

The studies concerning uveitis linked with another disease are multiple and are therefore well documented. Uveitis of undetermined origin is classified, by definition, as uveitis of non-infectious origin.

Anterior uveitis are available for local treatment prior to any discussion of introducing systemic treatment. Intermediate uveitis, posterior and panuveitis justify systemic treatment.

Systemic treatments used in these uveitis are METHOTREXATE, AZATHIOPRINE, MYCOPHENOLATE MOFETIL CICLOSPORINE, INTERFERON ALPHA, anti-TNF alpha. Antimetabolites (azathioprine, mycophenolate mofetil and methotrexate) are the most commonly used immunosuppressants.

Several randomized studies (retrospective or prospective) compared the use of METHOTREXATE (MTX) and MYCOPHENOLATE MOFETIL (MMF), in the management of non-infectious inflammatory ocular disease as a corticosteroid-sparing treatment.

Although MMF has a faster response time compared to MTX for inflammation control, the success rate is equivalent. These studies found no superiority of one molecule over the other .

There are no studies in the literature comparing the use of MTX versus AZA in treatment of these non-prior uveitis of undetermined origin. These two molecules are frequently used in our center as first-line treatment of idiopathic uveitis in an undifferentiated way.

The objective of this study is therefore to determine whether one of these molecules should be preferred for the management of our patients.

Inclusion Criteria:

• Patient age>18 years
• Intermediate, posterior or panuveitis diagnosed clinically by an ophthalmologist.
• Patient treated with azathioprine or methotrexate

Exclusion Criteria:

• Patient under legal protection
• Methotrexate dose < 10mg or azathioprine < 50mg
• Systemic or ophthalmological disease (Behçet, sarcoidosis, Retinopathy of Birdshot, etc.)
• Infectious uveitis
• Ophthalmological surgery < 30 days
• Delayed corticosteroid ocular implant > 3 months
• Introduction of biotherapy simultaneously or prior to immunosuppressive treatment

Patients with uveitis (intermediate, posterior or panuveitis) of undetermined origin diagnosed and or followed between January 2005 and March 2020 at the CHRU of Brest and who received treatment with methotrexate or azathioprine.

All collected data that underlie results in a publication

Data will be available beginning three years and ending fifteen years following the final study report completion

Data access requests will be reviewed by the internal committee of Brest UH. Requestors will be required to sign and complete a data access agreement.