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The aim of this study is to evaluate whether ultrasound measurements of the Qcsa can be utilized to identify older patients who are at risk for functional decline, ED revisit or death.
Background:
Older people visit the Emergency Department (ED) more frequently then younger people and have a higher risk of functional decline, ED revisit or death. Several screening tools (such as the Dutch safety management system (VMS) and Acutely Presenting Older Patient (APOP)) have been developed to identify patients at the highest risk of adverse outcomes. Almost all require adequate communication with the patient, which is not always possible, for example when elderly patients present with a delirium. Point of Care Ultrasonography (POCUS) may be a valuable alternative screening tool in these instances.
Main research question:
To identify whether POCUS measurement of the rectus femoris muscle cross-sectional area (Qcsa) can be used as an alternative screening tool to predict functional decline, ED revisit or death in elderly patients in the ED.
Design (including population, confounders/outcomes):
This is a single centre prospective trial. Patients >70 years and older presenting in the ED of the University Medical Centre Groningen (UMCG) who are participating in the Acutelines bio-databank are eligible for inclusion. 68 patients will be included. Data will be extracted from the Acutelines bio-databank. A trained physician will perform ultrasound measurements in a standardized way.
Expected results:
The aim of this study is to evaluate whether ultrasound measurements of the Qcsa can be utilized to identify older patients who are at risk for functional decline, ED revisit or death.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ultrasound | Device | Ultrasound measurements of the Qcsa |
| Measure | Description | Time Frame |
|---|---|---|
| Ultrasound Qcsa | POCUS Qcsa in older patients in the ED. | 1 day of admission to ED |
| ED revisit | Is there a relation between the performed POCUS Qcsa measurement at ED visit and ED revisit in older patients. | 3 months |
| Mortality | Is there a relation between the performed POCUS Qcsa measurement at ED visit and mortality in older patients. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| ED revisit: Ultrasound Qcsa versus Karnofsky Performance Score | To compare the ability of the Qcsa ultrasound versus the Karnofsky Performance Score (gold standard) to predict ED revisit in older patients in the ED. | 3 months |
| Mortality: Ultrasound Qcsa versus Karnofsky Performance Score |
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Inclusion Criteria:
Exclusion Criteria:
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Patients >70 years and older presenting in the ED of the UMCG hospital who are participating in the Acutelines bio-databank are eligible for inclusion.
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| Name | Affiliation | Role |
|---|---|---|
| Svenja Haak | University Medical Center Groningen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UMCG | Groningen | Netherlands |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41328618 | Derived | Haak SL, Giezen L, Blanca D, Bouma HR, Lameijer H, Ter Maaten JC, Ter Avest E. Point-of-Care Ultrasound-Based Assessment of Sarcopenia to Predict Revisits or Mortality in Older Adults at the Emergency Department: A Prospective Observational Study. Ann Geriatr Med Res. 2026 Mar;30(1):77-84. doi: 10.4235/agmr.25.0106. Epub 2025 Nov 3. |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Nov 24, 2021 | Mar 21, 2022 | Prot_SAP_000.pdf |
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| ID | Term |
|---|---|
| D000073496 | Frailty |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D014463 | Ultrasonography |
| ID | Term |
|---|---|
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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To compare the ability of the Qcsa ultrasound versus the Karnofsky Performance Score (gold standard) to predict mortality in older patients in the ED. |
| 3 months |
| ED revisit: Ultrasound Qcsa plus Karnofsky Performance Score | To compare the added value of Qcsa ultrasound versus the Karnofsky Performance Score (gold standard) to predict ED revisit in older patients in the ED. | 3 months |
| Mortality: Ultrasound Qcsa plus Karnofsky Performance Score | To compare the added value of Qcsa ultrasound versus the Karnofsky Performance Score (gold standard) to predict mortality in older patients in the ED. | 3 months |