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| ID | Type | Description | Link |
|---|---|---|---|
| CDMRP-SC210078 | Other Grant/Funding Number | Congressionally Directed Medical Research Programs (CDMRP) |
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| Name | Class |
|---|---|
| United States Department of Defense | FED |
| Congressionally Directed Medical Research Programs | FED |
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This study is a pilot clinical trial to explore the efficacy of transcutaneous spinal cord stimulation (TCSCS) (proof-of-concept) in mitigating crucial autonomic dysfunctions that impact the health-related quality of life of individuals with spinal cord injury (SCI).
This is a pilot clinical trial to explore the efficacy of TCSCS (proof-of-concept) in mitigating crucial autonomic dysfunctions that impact the health-related quality of life of individuals with SCI. A total of 30 eligible participants will be recruited and attend forty-two visits. All experiments will be performed at ICORD (Primary site) and the Brenda and David McLean Integrated Spine Clinic (SCI clinic), with the exception of anorectal manometry testing conducted at the Gastroenterology Clinic, St Paul's Hospital (GI clinic).
Following completion of screening and signing informed consent forms (visit 1), participants will undergo spatiotemporal mapping of spinal cord segments known to be involved in blood pressure, lower urinary tract and bowel control (visit 2). Following mapping, all individuals will undergo baseline functional assessments with and without TCSCS during 5 visits (visits 3-7), over a period of 4 weeks. To minimize the order effect, the functional assessments will be performed in a randomized order. Following baseline assessments, using a randomized counter-balanced approach, individuals will be allocated in two distinct pathways; the participants in Groups 1 and 2 will receive 8 weeks of TCSCS (3 times/week) at either mid/low thoracic or lumbosacral spinal cord levels respectively (visits 8- 31). Following long-term TCSCS, participants will undergo functional assessments during 5 visits (visits 32- 36) over a period of 4 weeks. In order to evaluate the persistent effects of TCSCS, all assessments will be repeated 8 weeks after cessation of the therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 - Thoracic stimulation | Experimental | Participants will receive 8 weeks TCSCS at the mid/low thoracic spinal cord levels. |
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| Group 2- Lumbosacral stimulation | Experimental | Participants will receive 8 weeks TCSCS at the lumbosacral spinal cord levels. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| TESCoN or SCONE device - Thoracic stimulation | Device | TCSCS will be delivered using a non-invasive central nervous system stimulator (TESCoN or SCONE, SpineX Inc., CA, USA). The stimulation site will be over the thoracic spinal cord. |
| Measure | Description | Time Frame |
|---|---|---|
| Targeted TCSCS map modulate resting blood pressure (BP) | Using continuous beat-by beat BP monitoring via finger photoplethysmography during TCSCS, the researchers will identify the location and stimulation parameters to increase and decrease resting BP. Stimulation site will be either on the thoracic spinal cord (T7-T12) or the lumbosacral spinal cord (L1 - L3). Stimulation will be applied at various frequencies ranging between 1Hz and 90Hz. The outcome is an individualized TCSCS map (i.e. location and stimulation parameters) with change in systolic BP at rest during TCSCS. | Week 1-2 (once) |
| Targeted TCSCS map to activate skeletal muscles and pelvic floor muscles | Using surface electromyography (EMG), the researchers will identify the motor threshold for skeletal muscles known to be involved in lower urinary tract, bowel and sexual control by delivering TCSCS at various spinal cord segments (T7 to conus medullaris). The outcome is an individualized TCSCS map (i.e. location and stimulation parameters) with pertinent motor thresholds for TCSCS-driven surface EMG. | Week 1-2 (once) |
| Immediate change in BP during the head up tilt test (HUTT) | During HUTT, participants will be passively moved to approximately 60° upright stand position by the investigators using the tilt table. Using TCSCS to activate spinal sympathetic circuitry and mitigate low resting BP and orthostatic hypotension (OH), and continuous beat-by beat BP monitoring via finger photoplethysmography, researchers will test the safety and efficacy of short-term TCSCS in reproducibly improving OH triggered by HUTT. | Week 3 - 6 (once) |
| Change in BP during the head up tilt test (HUTT) from baseline to after completion of 8 weeks of TCSCS | Using TCSCS and continuous beat-by beat BP monitoring via finger photoplethysmography, researchers will test the safety and efficacy of long-term TCSCS in improving OH triggered by HUTT. | Week 15-18 (once) |
| Measure | Description | Time Frame |
|---|---|---|
| Immediate change in cerebral blood flow (CBF) measured by trans-cranial doppler (TCD) during HUTT | TCD is a non-invasive ultrasound technique used to measure real-time CBF velocity. Researchers will test the safety and efficacy of short-term TCSCS in reproducibly improving CBF during HUTT. | Week 3 - 6 (once) |
| Measure | Description | Time Frame |
|---|---|---|
| Frequency of urinary incontinence will be measured using The Incontinence-Quality of Life (I-QoL) questionnaire. | Assessment of urinary incontinence will be performed to assess the impact of long term TCSCS on this measure. The scale is a 100 point scale where 0 is most severe incontinence. | Week 3 - 6 (once), Week 15-18 (once), week 27-30 (once) |
Inclusion Criteria:
Resident of British Columbia, Canada with active provincial medical services plan.
Male or female, 19-60 years of age.
Chronic traumatic SCI (non-progressive, with complete motor paralysis) at or above the T6 spinal segment.
>1-year post injury, at least 6 months from any spinal surgery.
American Spinal Injury Association Impairment Scale (AIS) A, B.
Stable management of spinal cord related clinical issues (i.e., spasticity management).
Experience bladder, or bowel, or sexual dysfunction.
No painful musculoskeletal dysfunction, unhealed fracture, pressure sore, or active infection that may interfere with testing.
For women of childbearing potential, not intending to become pregnant, currently pregnant, or lactating. The following conditions apply:
For sexually active males with female partners of childbearing potential, use adequate contraception, or complete abstinence from sexual activities, during the period of the trial and for at least 28 days after completion of treatment.
Must provide informed consent.
Willing and able to comply with all clinic visits and study-related procedures.
Able to understand and complete study-related questionnaires (must be able to understand and speak English or have access to an appropriate interpreter as judged by the investigator).
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Andrea L. Maharaj, BSc | Contact | 604-675-8856 | AMaharaj@icord.org | |
| Soshi Samejima, PhD | Contact | 604 675 8816 | soshi@icord.org |
| Name | Affiliation | Role |
|---|---|---|
| Andrei Krassioukov, MD, PhD, FRCPC | The University of British Columbia, International Collaboration on Repair Discoveries (ICORD) | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Blusson Spinal Cord Centre | Recruiting | Vancouver | British Columbia | V5Z 1M9 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42203266 | Derived | Malik RN, Sobeeh MG, Maharaj AL, Shackleton C, Hosseinzadeh A, Saloojee M, Khavandegar A, Kontaxakis A, Thordarson T, Chang C, Balthazaar SJT, Williams AMM, Lam T, Ghuman A, Anderson K, Elliott SL, Berger MJ, Samejima S, Sachdeva R, Krassioukov AV. Moving from mechanisms to clinical practice: non-invasive spinal cord stimulation for recovery of autonomic functions after spinal cord injury - a protocol for a pilot randomised controlled trial. BMJ Open. 2026 May 27;16(5):e119795. doi: 10.1136/bmjopen-2026-119795. | |
| 42152086 |
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The research team plans to deposit final de-identified research data at a community-based repository for SCI research, such as Open Data Commons for SCI (https://odc-sci.org//). Research resources, including but not limited to, established stimulation parameter and recording equipment, will also be made available through material transfer agreement upon reasonable request.
Data will be available upon full-text print publication in a peer-reviewed journal, for a duration of at least 10 years.
Online access or e-mail request to the corresponding author from an established scientific investigator
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Using a randomized counter-balanced approach, individuals will be allocated in two distinct pathways; the participants in Groups 1 (thoracic stimulation) and Group 2 (lumbosacral stimulation) will receive 8 weeks of TCSCS (3 times/week) at either mid/low thoracic or lumbosacral spinal cord levels respectively.
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| TESCoN or SCONE device - Lumbosacral stimulation | Device | TCSCS will be delivered using a non-invasive central nervous system stimulator (TESCoN or SCONE, SpineX Inc., CA, USA). The stimulation site will be over the lumbosacral spinal cord. |
|
| Change in BP during the head up tilt test (HUTT) from baseline to 8 weeks after cessation of TCSCS | Using TCSCS and continuous beat-by beat BP monitoring via finger photoplethysmography, researchers will test the safety and efficacy of long-term TCSCS in improving OH triggered by HUTT after cessation of therapy. | Week 27-30 (once) |
| Immediate change in BP during digital anorectal stimulation (DARS) | DARS is a routine procedure to initiate a bowel routine. The participant will lay on their right side and DARS will be delivered via an index finger inserted into the rectum, applying gentle pressure for 30-60s. Utilizing TCSCS to inhibit nociceptive afferent and continuous beat-by beat BP monitoring via finger photoplethysmography, researchers will test the safety and efficacy of short-term TCSCS in reproducibly improving autonomic dysreflexia (AD) triggered by DARS. | Week 3 - 6 (once) |
| Change in BP during digital anorectal stimulation (DARS) from baseline to after completion of 8 weeks of TCSCS | Utilizing TCSCS and continuous beat-by beat BP monitoring via finger photoplethysmography, researchers will test the safety and efficacy of long-term TCSCS in improving AD triggered by DARS. | Week 15-18 (once) |
| Change in BP during digital anorectal stimulation (DARS) from baseline to 8 weeks after cessation of TCSCS | Utilizing TCSCS and continuous beat-by beat BP monitoring via finger photoplethysmography, researchers will test the safety and efficacy of TCSCS in improving AD triggered by DARS after cessation of therapy. | Week 27-30 (once) |
| Immediate change in rectal pressure measured by anorectal manometry (ARM) | ARM is well-established methodology that provides a direct assessment of anal sphincter pressure and anorectal coordination during simulated defecation. The test is performed by inserting a catheter, that contains a probe embedded with pressure sensors, through the anus and into the rectum. Researchers will test the safety and efficacy of short-term TCSCS in reproducibly changing average max resting and squeeze pressure (mmHg). | Week 3 - 6 (once) |
| Immediate change in high pressure anal canal zone measured by ARM | Researchers will test the safety and efficacy of short-term TCSCS in reproducibly changing length of high pressure anal canal zone (cm). | Week 3 - 6 (once) |
| Immediate change in recto-anal inhibitory reflex measured by ARM | Researchers will test the safety and efficacy of short-term TCSCS in reproducibly changing recto-anal inhibitory reflex. | Week 3 - 6 (once) |
| Immediate change in rectal sensation measured by ARM | Researchers will test the safety and efficacy of short-term TCSCS in reproducibly changing rectal sensation (mL). | Week 3 - 6 (once) |
| Change in rectal pressure measured by ARM from baseline to after completion of 8 weeks of TCSCS | Utilizing TCSCS and ARM, researchers will test the safety and efficacy of long-term TCSCS in changing average max resting and squeeze pressure (mmHg). | Week 15-18 (once) |
| Change in high pressure anal canal zone measured by ARM from baseline to after completion of 8 weeks of TCSCS | Utilizing TCSCS and ARM, researchers will test the safety and efficacy of long-term TCSCS in changing length of high pressure anal canal zone (cm). | Week 15-18 (once) |
| Change in rectal sensation measured by ARM from baseline to after completion of 8 weeks of TCSCS | Utilizing TCSCS and ARM, researchers will test the safety and efficacy of long-term TCSCS in changing rectal sensation (mL). | Week 15-18 (once) |
| Change in recto-anal inhibitory reflex measured by ARM from baseline to after completion of 8 weeks of TCSCS | Utilizing TCSCS and ARM, researchers will test the safety and efficacy of long-term TCSCS in changing recto-anal inhibitory reflex. | Week 15-18 (once) |
| Change in rectal pressure measured by anorectal manometry (ARM) from baseline to 8 weeks after cessation of TCSCS | Utilizing TCSCS and ARM, researchers will test the safety and efficacy of TCSCS in changing average max resting and squeeze pressure (mmHg). | Week 27-30 (once) |
| Change in high pressure anal canal zone measured by anorectal manometry (ARM) from baseline to 8 weeks after cessation of TCSCS | Utilizing TCSCS and ARM, researchers will test the safety and efficacy of TCSCS in changing length of high pressure anal canal zone (cm). | Week 27-30 (once) |
| Change in recto-anal inhibitory reflex measured by anorectal manometry (ARM) from baseline to 8 weeks after cessation of TCSCS | Utilizing TCSCS and ARM, researchers will test the safety and efficacy of TCSCS in changing recto-anal inhibitory reflex. | Week 27-30 (once) |
| Change in rectal sensation measured by anorectal manometry (ARM) from baseline to 8 weeks after cessation of TCSCS | Utilizing TCSCS and ARM, researchers will test the safety and efficacy of TCSCS in changing rectal sensation (mL). | Week 27-30 (once) |
| Immediate change in intravesical pressure at first sensation measured by urodynamic investigation (UDI) | Standard clinical procedures for UDI, including cystometry with water at 21°C and a filling rate of < 30 mL per minute through a 6F double lumen catheter with the participants in the supine position, provides a direct assessment of voiding and storage function. Abdominal pressure will be measured with a 10F intrarectal balloon catheter. Filling will be stopped when the participants report a sensation of fullness. Researchers will test the safety and efficacy of short-term TCSCS in reproducibly changing intravesical pressure at first sensation (mmHg). | Week 3 - 6 (once) |
| Immediate change in intravesical pressure at leakage point measured by UDI | Filling will be stopped at the moment of urine leakage. Researchers will test the safety and efficacy of short-term TCSCS in reproducibly changing intravesical pressure at leakage point (mmHg). | Week 3 - 6 (once) |
| Immediate change in intravesical pressure at maximal volume measured by UDI | Filling will be stopped at the moment of discomfort/per the request of patient. Researchers will test the safety and efficacy of short-term TCSCS in reproducibly changing intravesical pressure at maximal volume (mmHg). | Week 3 - 6 (once) |
| Change in intravesical pressure at first sensation measured by UDI from baseline to after completion of 8 weeks of TCSCS | Utilizing TCSCS and UDI, researchers will test the safety and efficacy of long-term TCSCS in changing intravesical pressure at first sensation (mmHg). | Week 15-18 (once) |
| Change in intravesical pressure at leakage point measured by UDI from baseline to after completion of 8 weeks of TCSCS | Utilizing TCSCS and UDI, researchers will test the safety and efficacy of long-term TCSCS in changing intravesical pressure at leakage point (mmHg). | Week 15-18 (once) |
| Change in intravesical pressure at maximal volume measured by UDI from baseline to after completion of 8 weeks of TCSCS | Utilizing TCSCS and UDI, researchers will test the safety and efficacy of long-term TCSCS in changing intravesical pressure at maximal volume (mmHg). | Week 15-18 (once) |
| Change in intravesical pressure at first sensation measured by UDI from baseline to 8 weeks after cessation of TCSCS | Utilizing TCSCS and UDI, researchers will test the safety and efficacy of TCSCS in changing intravesical pressure at first sensation (mmHg). | Week 27-30 (once) |
| Change in intravesical pressure at leakage point measured by UDI from baseline to 8 weeks after cessation of TCSCS | Utilizing TCSCS and UDI, researchers will test the safety and efficacy of TCSCS in changing intravesical pressure at leakage point (mmHg). | Week 27-30 (once) |
| Change in intravesical pressure at maximal volume measured by UDI from baseline to 8 weeks after cessation of TCSCS | Utilizing TCSCS and UDI, researchers will test the safety and efficacy of TCSCS in changing intravesical pressure at maximal volume (mmHg). | Week 27-30 (once) |
| Immediate change in BP during penile or clitoral vibrostimulation | Genital vibration will be applied by an experienced physician using one or more handheld vibrators placed about the glans penis or the clitoral area with an amplitude of 1.0-3.5 mm and a frequency of 70-100 Hz. Utilizing TCSCS to inhibit nociceptive afferent and continuous beat-by beat BP monitoring via finger photoplethysmography, researchers will test the safety and efficacy of short-term TCS in reproducibly improving AD triggered by vibrostimulation. | Week 3 - 6 (once) |
| Change in BP during penile or clitoral vibrostimulation from baseline to after completion of 8 weeks of TCSCS | Utilizing TCSCS and continuous beat-by beat BP monitoring via finger photoplethysmography, researchers will test the safety and efficacy of long-term TCSCS in improving AD triggered by vibrostimulation. | Week 15-18 (once) |
| Change in BP during penile or clitoral vibrostimulation from baseline to 8 weeks after cessation of TCSCS | Utilizing TCSCS to inhibit nociceptive afferent and continuous beat-by beat BP monitoring via finger photoplethysmography, researchers will test the safety and efficacy of TCSCS in improving AD triggered by vibrostimulation. | Week 27-30 (once) |
| Baseline assessment of colonic motility using the wireless motility capsule | The wireless motility capsule will be ingested and pass naturally through the GI tract, and data will be sent wirelessly to the data receiver. Researchers will use the collected data to assess baseline transit times. | Week 3 - 6 (once) |
| Change in colonic motility using the wireless motility capsule from baseline to after completion of 8 weeks of TCSCS | Utilizing TCSCS and the wireless motility capsule, researchers will test the safety and efficacy of long-term TCSCS in improving transit times. | Week 15-18 (once) |
| Change in colonic motility using the wireless motility capsule from baseline to 8 weeks after TCSCS cessation. | Utilizing TCSCS and the wireless motility capsule, researchers will test the safety and efficacy of TCSCS in improving transit times after cessation of therapy. | Week 27-30 (once) |
| Change in CBF measured by TCD during HUTT from baseline to after completion of 8 weeks of TCSCS |
Researchers will test the safety and efficacy of long-term TCSCS in improving CBF during HUTT. |
| Week 15-18 (once) |
| Change in CBF measured by TCD during HUTT from baseline to 8 weeks after TCSCS cessation | Researchers will test the safety and efficacy of TCSCS in improving CBF during HUTT after cessation of therapy. | Week 27-30 (once) |
| Immediate change in performance on the verbal fluency test (VFT) during HUTT | Phonetic/letter fluency, specifically total number of words, will be measured using the verbal fluency test (VFT). Researchers will test the safety and efficacy of short-term TCSCS in reproducibly improving cognitive function during HUTT. | Week 3 - 6 (once) |
| Change in performance on the VFT from baseline to after completion of 8 weeks of TCSCS | Researchers will test the safety and efficacy of long-term TCSCS in improving phonetic/letter fluency using the VFT. | Week 15-18 (once) |
| Change in performance on the VFT from baseline to 8 weeks after TCSCS cessation | Researchers will test the safety and efficacy of TCSCS in improving phonetic/letter fluency after cessation of therapy. | Week 27-30 (once) |
| Immediate change in performance on the Stroop Color and Word (SCW) test during HUTT | Ability to inhibit cognitive interference, specifically completion time, will be measured using the Stroop Color and Word (SCW) test. Researchers will test the safety and efficacy of short-term TCSCS in reproducibly improving completion time of the SCW. | Week 3 - 6 (once) |
| Change in performance on SCW from baseline to after completion of 8 weeks of TCSCS | Researchers will test the safety and efficacy of short-term TCSCS in reproducibly improving completion time of the SCW. | Week 15-18 (once) |
| Change in performance on SCW from baseline to 8 weeks after TCSCS cessation | Researchers will test the safety and efficacy of short-term TCSCS in reproducibly improving completion time of the SCW after cessation of therapy. | Week 27-30 (once) |
| Neurogenic bladder symptoms will be measured using the Neurogenic Bladder Symptom Score (NBSS). |
Assessment of neurogenic bladder symptoms will be performed to assess the impact of long term TCSCS on this measure. The score measures bladder symptoms across 3 different domains: incontinence (scored 0-29), storage and voiding (scored 0-22), and consequences (scored 0-23), with higher scores representing worse symptoms. |
| Week 3 - 6 (once), Week 15-18 (once), week 27-30 (once) |
| Frequency of fecal incontinence will be measured using the modified Wexner Fecal Incontinence Score (WIS). | Assessment of fecal incontinence will be performed to assess the impact of long term TCSCS on this measure. Scores can range from 0-20, with a higher score representing greater incontinence. | Week 3 - 6 (once), Week 15-18 (once), week 27-30 (once) |
| Neurogenic bowel symptoms will be measured using the Neurogenic Bowel Dysfunction (NBD) score. | Assessment of neurogenic bowel symptoms will be performed to assess the impact of long term TCSCS on this measure. Scores can range from 0-47, with a higher score representing more severe dysfunction. | Week 3 - 6 (once), Week 15-18 (once), week 27-30 (once) |
| Time Needed for Bowel Movement (TNFBM) will be measured by self-report. | Participants will be asked to record the time from 'suppository insertion' to 'when bowel evacuation is completed', during their regular bowel movement at home. | Week 3 - 6 (once), Week 15-18 (once), week 27-30 (once) |
| Participant's sexual function and satisfaction with their overall sexual life will be measured using the International Index of Erectile Function (IIEF-15). | This measure of sexual function will be used to assess whether sexual function is impacted by TCSCS. Scores can range from 5-25, with higher scores representing greater function. | Week 3 - 6 (once), Week 15-18 (once), week 27-30 (once) |
| Participant's sexual function and satisfaction with their overall sexual life will be measured using the Female Sexual Function Index (FSFI). | This measure of sexual function will be used to assess whether sexual function is impacted by TCSCS. Scores can range from 2-36, with higher scores representing greater function. | Week 3 - 6 (once), Week 15-18 (once), week 27-30 (once) |
| Participant's sexual function and satisfaction with their overall sexual life will be measured using a semi-structured qualitative interview. | This measure of sexual function will be used to assess whether sexual function is impacted by TCSCS. | Week 3 - 6 (once), Week 15-18 (once), week 27-30 (once) |
| Participant's sexually related personal distress will be measured using the Female Sexual Distress Scale (FSDS). | The FSDS is a 13-item self-report measure of sexually related personal distress in women. The 13 items of the scale are scored on a 5-point Likert scale ranging from 0 (never) to 4 (always). The total score is calculated as the sum of the responses and ranges from 0 to 52, with higher scores indicating a greater level of distress. A score of ≥11 serves as a cut-off value for diagnosing women with sexual distress. | Week 3 - 6 (once), Week 15-18 (once), week 27-30 (once) |
| Participant's sensations associated with orgasm will be measured using the Orgasm Rating Scale (ORS). | The ORS is a 28 item self-report measure of phenomenological sensations associated with orgasm in men and women. Items are scored from 0 (not at all) 5 (extremely), with total scores ranging from 0 to 140, and higher scores indicating better function. | Week 3 - 6 (once), Week 15-18 (once), week 27-30 (once) |
| Participant's quality of life will be measured using the Short Form Health Survey (SF-36) | The SF-36 consists of 8 domains pertaining to the respondents' experiences in the last 4 weeks. Each of the 8 summed scores is linearly transformed onto a scale from 0 (negative health) to 100 (positive health) to provide a score for each subscale. | Week 3 - 6 (once), Week 15-18 (once), week 27-30 (once) |
| St Paul's Hospital | Recruiting | Vancouver | British Columbia | V6Z 1Y6 | Canada |
|
| Derived |
| Malik RN, Samejima S, Williams AMM, Hosseinzadeh A, Ogalo E, Stolz A, Lam C, Shackleton C, Miller T, Sobeeh MG, Boyd LA, Kramer JLK, Lam T, Sachdeva R, Berger MJ, Krassioukov AV. Non-invasive spinal cord neuromodulation enables volitional anti-gravity leg movements after motor-complete spinal cord injury: responders vs. non-responders. J Neuroeng Rehabil. 2026 May 18. doi: 10.1186/s12984-026-02011-9. Online ahead of print. |
| ID | Term |
|---|---|
| D013119 | Spinal Cord Injuries |
| D054969 | Primary Dysautonomias |
| D012735 | Sexual Dysfunction, Physiological |
| D020211 | Autonomic Dysreflexia |
| D007024 | Hypotension, Orthostatic |
| ID | Term |
|---|---|
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D001342 | Autonomic Nervous System Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D054971 | Orthostatic Intolerance |
| D007022 | Hypotension |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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