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Conscious attempts to regulate alcohol use are often undermined by automatic attention and arousal processes activated by alcohol cues, as well as by diminished ability to inhibit in-the-moment behaviors. The current study will examine whether a brief behavioral intervention of slow breathing paced at a resonance frequency of the cardiovascular system can interrupt automatic alcohol cue reactivity and enhance cognitive control in binge drinkers. Results from the proposed study may provide new prevention and intervention targets to interrupt unhealthy drinking behaviors.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Resonance paced breathing | Experimental | Active resonance breathing task consisting of synchronizing breathing with a visual pacer (E-Z Air, Thought Technology, Ltd., Plattsburgh, NY) that moves up (inhale) and down (exhale) at the rate of 0.1 Hz (6 breaths per min) |
|
| Low demand vanilla control | Active Comparator | A low-demand cognitive "vanilla" task wherein different colored rectangles are presented for 10 sec each, and participants are instructed to silently count the number of blue rectangles |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Resonance breathing | Behavioral | Participants will synchronize their breathing with a visual pacer (E-Z Air, Thought Technology, Ltd., Plattsburgh, NY) that moves up (inhale) and down (exhale) at the rate of 0.1 Hz (6 breaths per min) |
| Measure | Description | Time Frame |
|---|---|---|
| N2 ERP amplitude (in microvolts) elicited from an Alcohol Cued Go/No-Go task | The N2 component (in microvolts) of the event-related potential occurring 250-350 ms after stimulus presentation at frontal and central electrode sites during an Alcohol Cued Go/No-Go task following a 5-minute course of resonance breathing compared to a low-demand control task | Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart |
| N2pc ERP amplitude (in microvolts) elicited from a visual dot probe detection task | The N2pc component of the event-related potential occurring 200-275 ms after stimulus presentation at parietal and occipital electrode sites (ipsilateral minus contralateral hemisphere activity) during a modified visual dot probe detection task following a 5-minute course of resonance breathing compared to a low-demand control task | Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart |
| P3b ERP amplitude (in microvolts) elicited from a picture-viewing task | The P3b component of the event-related potential occurring 300-600 ms after stimulus presentation at central and parietal electrode sites during a picture viewing task following a 5-minute course of resonance breathing compared to a low-demand control task | Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart |
| N2 ERP latency (in milliseconds) elicited from an Alcohol Cued Go/No-Go task | The latency of the N2 component of the event-related potential from frontal and central electrode sites during a picture viewing task following a 5-minute course of resonance breathing compared to a low-demand control task. Latency will be determined using 50% area latency from a difference wave between task conditions | Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart |
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Inclusion Criteria:
Exclusion Criteria:
Participants will self-identify gender identity on an approved demographic questionnaire
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| Name | Affiliation | Role |
|---|---|---|
| Brandon L Alderman, Ph.D. | Rutgers, The State University of New Jersey | Principal Investigator |
| Marsha E Bates, Ph.D. | Rutgers, The State University of New Jersey | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rutgers, The State University of New Jersey | New Brunswick | New Jersey | 08901 | United States |
We plan to share data via the NIAAA Data Archive (NIAAADA) repository within the larger National Institute of Mental Health (NIMH) Data Archive (NDA).
Data generated by the proposed project include the following information on participants (male and female) aged 18-35 years:
Surveys:
Electrophysiological Data:
At the conclusion of data collection and no later than 24 months after the NIH award end date or 6 months post-publication of the final data set (whichever date occurs first). There is no restriction for how long the data will be available.
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| ICF | No | No | Yes | Informed Consent Form | May 20, 2022 | Jan 27, 2025 | ICF_000.pdf |
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| ID | Term |
|---|---|
| D063425 | Binge Drinking |
| D000428 | Alcohol Drinking |
| D053120 | Respiratory Aspiration |
| D004327 | Drinking Behavior |
| ID | Term |
|---|---|
| D019973 | Alcohol-Related Disorders |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001519 | Behavior |
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Subjects will complete an active treatment of slow resonance paced breathing and a control visual color block task on separate days, separated by approximately one week
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| Low demand cognitive task | Behavioral | Different colored rectangles are presented for 10 sec each, and participants are instructed to silently count the number of blue rectangles |
|
| N2pc ERP latency (in milliseconds) elicited from a visual dot probe detection task | The latency of the N2pc component of the event-related potential from parietal and occipital electrode sites during a visual dot probe detection task following a 5-minute course of resonance breathing compared to a low-demand control task. Latency will be determined using 50% area latency from a difference wave between task conditions | Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart |
| P3b ERP latency (in milliseconds) elicited from a picture-viewing task | The latency of the P3b component of the event-related potential from central and parietal electrode sites during a picture viewing task following a 5-minute course of resonance breathing compared to a low-demand control task. Latency will be determined using 50% area latency from a difference wave between task conditions | Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart |
| Task accuracy from the behavioral response during the Alcohol Cued Go/No-Go task | Task accuracy as a percentage of correct behavioral responses to the task during the Alcohol Cued Go/No-Go ERP task following a 5-minute course of resonance breathing compared to a low-demand control task | Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart |
| Reaction time from the behavioral response during the Alcohol Cued Go/No-Go task | Reaction time for the correct behavioral responses to the task measured in milliseconds during the Alcohol Cued Go/No-Go ERP task following a 5-minute course of resonance breathing compared to a low-demand control task | Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart |
| Task accuracy from the behavioral response during the visual dot probe detection task | Task accuracy as a percentage of correct behavioral responses to the task during the visual dot probe detection task following a 5-minute course of resonance breathing compared to a low-demand control task | Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart |
| Reaction time from the behavioral response during the visual dot probe detection task | Reaction time for the correct behavioral responses to the task measured in milliseconds during the visual dot probe ERP task following a 5-minute course of resonance breathing compared to a low-demand control task | Immediate; Difference between the active resonance breathing compared to the low demand cognitive task occurring one week apart |
| D001523 | Mental Disorders |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |